More specifically, once a lipophilic chemical is inside the human body, it will not go away any time soon. In some instances, a large enough dose can induce an acute adverse effect such as a birth defect, or can activate the initiation of a cancer’s development if the chemical acts as an initiator. Thus certain damage can be induced with doses received simply from a short exposure duration. The point being made here is that the ADI or RfD used for tolerance derivation did not seem to take into consideration the possibly significant extra amount of a POC arising from sources other than fish consumption. Meantime, all the toxicity studies conducted thus far could not afford the testing of synergistic or additive adverse effects of these chemicals.