Petersen et al. (2006) Molecular Cell 21: 533-542.

Figure 7. Short RNAs Repress Translation af- ter Initiation in Human Cells Short RNA complexes associated with Argo- naute proteins bind with mismatches to the 30 UTR of a target gene and act at a distance to cause drop-off of translating ribosomes at multiple sites within the ORF. A very small in- crease in drop off frequency at multiple sites would significantly decrease the synthesis of full-length polypeptides. Note that if the initi- ation rate is sufficiently high, such ribosome drop off would not significantly decrease ri- bosome loading.