Might Interleukin-6 than play a role in atherogenesis? This observation suggest that small degrees of elevation of circulating IL-6 levels may play a downstream role not only in elevating other cytokines but also a role in atherogenesis itself. The proposal is then that these proinflammatory cytokines may act as common antecedent linking at one hand insulin resistance, on the other, microalbuminuria, activation of endothelial cells and in long term the atherotrombotic processes of cardiovascular diseases. Proinflammatory cytokines may cause generation of fibrinogen and some important components of thrombosis as well as any effects that may have on atherogenesis.