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NIA is collaborating with the Icelandic Heart Association, Reykjavik, Iceland for a multi-year research study to investigate genetic susceptibility and gene-environment interaction in health conditions common in old age. The population to be studied in this project is a unique established longitudinal cohort study in Iceland, the Reykjavik Study, under the supervision of the Icelandic Heart Association. The contractor proposes to re-examine surviving cohort members, approximately 12,000 survivors aged 65 and over, in either a clinic or at home. Contract review and the negotiation process are underway.