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Honolulu-Asia Aging Study (HAAS) The primary goal of HAAS is to provide data on the pathogenesis and etiologies of dementia and cognitive impairment. Secondary goals include research on Parkinson’s disease, stroke, other neurologic conditions (such as cortical Lewy body disease), sleep apnea, diabetes, longevity and genetic epidemiology. Currently there are 1,500 men in the cohort.  The HAAS has the special opportunity to examine the impacts of Japanese cultural and genetic factors on dementia, and to use a wealth of prospectively collected information in a search for dementia-related risk factors. Additionally, the HAAS study design includes acquisition of standardized anatomic/pathologic information from magnetic resonance imaging (MRI) and from autopsy. In 1999, the collaborators conducted Exam 6 to ascertain more dementia cases as well as disease status since the first NIA-sponsored examination in 1991-1993. The Exam 6 finished in March 1999, and consensus sessions to confirm dementia diagnoses will continue through December 2000. Also in March 1999, a new sleep study was initiated to ascertain episodes of sleep apnea using NHLBI methods and procedures to allow comparisons with other ongoing studies. The autopsy acquisition protocol for neuropathology will continue for 5 more years with grant funding to maintain specimen collection, analysis, and reporting. The current contract is due to end in June 2001.