This is some interesting data. The Winawer study was the National Polyp Study that took people with adenomas and then followed them with surveillance colonoscopy at one to three years up to six years. What they found after the observation was only five cases of cancer, and this was far less than historical controls. So they inferred from this that colonoscopy will wipe out colon cancer. There have been a bunch of polyp prevention trials, including one we participated in, the Schatzkin study, which took people with adenomas. It was a dietary intervention study using wheat bran to see if you could prevent the recurrence of adenomas. They looked at the cancer rate in these 2000 people that were being followed and in fact the incidence rate is not negligible by any means, and was in fact somewhat similar to C rate (?). What does this mean? It means first of all that colonoscopy is not perfect: people think they got to the end of the colon when they really didn’t, you can miss lesions with colonoscopy, or there are now a lot of data about flat adenomas – adenomas that are not so easily detectable – that maybe progress further on.