Fundamentally, colorectal cancer, like many cancers, is a disease of aging; as we age we have increased risk. That has tremendous implications for screening. First, on the one hand, of course, is the question of when to begin screening. The traditional age is age 50 if you’re of average risk. But more importantly, the area of the colon that becomes involved with cancer may change over time. We’re starting to see that in older people we have more proximal disease, further deep inside the colon. So if that happens, that has implications for using things like sigmoidoscopy, for example, which only examines the first half of the colon.