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Over the past few years, there is growing recognition that health systems research is a useful tool to empower policy makers in informed decision making. World-wide and especially in Africa, many initiatives were undertaken to strengthen HSR: the Commission of Health Research for Development (COHRED); the Commonwealth Regional Health Community Secretariat for East, Central and Southern Africa (CRHCS), the 'Joint Project on Health Systems Research' for the Eastern and Southern Africa Region - and the GTZ-supported Network for Health Systems Research for Reproductive Health and Health Care Reforms in Eastern and Southern Africa.