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Studies in order to find an autoimmune mechanism have demonstrated that there is wide information from patient's data pointing directly to a T-Cell activation that might have produced, at the same time, reactions against antigens of the own host's cells, thus converting an epidemic of external origin into a disease that needs the collaboration of the host's response to develop its complete spectrum.

Ten RM, Kephart GM, Posada de la Paz M, et al. Participation of eosinophils in the toxic oil syndrome. Clin Exp Immunol 1990;82(2):313-7.

Gallardo S, del Pozo V, Cardaba B, et al. Immunological basis of toxic oil syndrome (TOS). Toxicology 1994;93(2-3):289-99.