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The first Toxi-Epi study was limited to only two localities, so the conclusions might have been due to a confound variable linked to the two places involved. A further study that covered a wider geographical area was performed and results obtained were similar to the former.

Posada de la Paz M, Philen RM, Abaitua Borda I, et al. Factors associated with pathogenicity of oils related to the toxic oil syndrome epidemic in Spain. Epidemiology 1994;5(4):404-9.