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Isolates cause a spectrum of disease from subclinical respiratory tract infection, torticollis, to death and haemorrhages (the notifiable disease of fowl plague).

Hosts:
NDV is a world-wide disease of gallinaceous birds, e.g. chickens, guinea-fowl, turkeys, pheasants. NDV can also infect racing pigeons, psittacine birds and aquatic birds.
Man, conjunctivitis
, aerosol- vaccine operators should wear masks.

Diagnosis:
The trachea and gut of 20 birds are tested in eggs. If HA occurs an HI test is done using using reference anti-NDV serum to distinquish it from avian influenza.

Epidemiology:
Usually spread by poultry or air-borne. Unexpected UK outbreaks caused by dying pigeons being milled into chicken food in 1984. Currently controlled by import restrictions and vaccination using avirulent isolates in the UK.