Department of Environmental and Occupational Health

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Valerian E. Kagan - Publications

Peer-Reviewed Papers in the US and International Journals (last 5 years)

  1. Belikova NA, Jiang J, Tyurina YY, Zhao Q, Epperly MW, Greenberger J, Kagan VE. Cardiolipin-specific peroxidase reactions of cytochrome C in mitochondria during irradiation-induced apoptosis. Int J Radiat Oncol Biol Phys. 2007 Sep 1;69(1):176-86. PMID: 17707271

  2. Fink MP, Macias CA, Xiao J, Tyurina YY, Delude RL, Greenberger JS, Kagan VE, Wipf P. Hemigramicidin-TEMPO conjugates: novel mitochondria-targeted antioxidants. Crit Care Med. 2007 Sep;35(9 Suppl):S461-7. PMID: 17713394

  3. Kapralov AA, Kurnikov IV, Vlasova II, Belikova NA, Tyurin VA, Basova LV, Zhao Q, Tyurina YY, Jiang J, Bayir H, Vladimirov YA, Kagan VE. The Hierarchy of Structural Transitions Induced in Cytochrome c by Anionic Phospholipids Determines Its Peroxidase Activation and Selective Peroxidation during Apoptosis in Cells. Biochemistry. 2007 Nov 16. PMID: 18004876

  4. Shvedova, A.A., Fabisiak, J.P., Kisin, E.R., Murray, A., Roberts, J., Antonini, J., Kommineini, C., Reynolds, J., Barchwosky, A., Castranova, V., and Kagan, V.E. Sequential exposure to carbon nanotubes and bacteria enhances pulmonary inflammation and infectivity. Am. J. Respir. Cell Molec. Biol., 2007 Dec 20. PMID: 18096873

  5. Kisin ER, Murray AR, Keane MJ, Shi XC, Schwegler-Berry D, Gorelik O, Arepalli S, Castranova V, Wallace WE, Kagan VE, Shvedova AA. Single-walled carbon nanotubes: geno- and cytotoxic effects in lung fibroblast V79 cells. J Toxicol Environ Health A. 2007 Dec; 70 ( 24 ): 2071-9. PMID: 18049996

  6. Hoye AT, Davoren, JE, Wipf P, Fink MP, Kagan, VE. Targeting mitochondria. Acc Chem Res. 2008 Jan; 41 ( 1 ): 87-97. PMID: 18193822

  7. Tyurina YY, Tyurin VA, Epperly MW, Greenberger JS, Kagan VE. Oxidative lipidomics of gamma-irradiation-induced intestinal injury. Free Radic Biol Med. 2008 Feb 1; 44 ( 3 ): 299-314. Epub 2007 Sep 6. PMID: 18215738

  8. Stoyanovsky DA, Vlasova II, Belikova NA, Kapralov A, Tyurin V, Kagan VE. Activation of NO donors in mitochondria: Peroxidase metabolism of (2-hydroxyamino-vinyl)-triphenyl-phosphonium by cytochrome c releases NO and protects cells against apoptosis. FEBS Lett. 2008 Feb 5; PMID: 18258194

  9. Jiang J, Belikova NA, Hoye AT, Zhao Q, Epperly MW, Greenberger JS, Wipf P, Kagan VE. A mitochondria-targeted nitroxide/hemigramicidin s conjugate protects mouse embryonic cells against gamma irradiation. Int J Radiat Oncol Biol Phys. 2008 Mar 1; 70 ( 3 ): 816-25. PMID: 18262096

  10. Bayir H, Kagan VE.  Bench-to-bedside review: Mitochondrial injury, oxidative stress and apoptosis - there is nothing more practical than a good theory.  Crit Care. 2008 Feb 18;12(1):206 PMID: 18341705

  11. Huang Z, Jiang J, Tyurin VA, Zhao Q, Mnuskin A, Ren J, Belikova NA, Feng W, Kurnikov IV, Kagan VE.  Cardiolipin deficiency leads to decreased cardiolipin peroxidation and increased resistance of cells to apoptosis.  Free Radic Biol Med. 2008 Mar 13; PMID: 18375209

  12. Tyurin VA, Tyurina YY, Kochanek PM, Hamilton R, Dekosky ST, Greenberger JS, Bayir H, Kagan VE.  Chapter nineteen oxidative lipidomics of programmed cell death.  Methods Enzymol. 2008;442:375-93.   PMID: 18662580

  13. Allen BL, Kichambare PD, Gou P, Vlasova II, Kapralov AA, Konduru N, Kagan VE, Star A.  Biodegradation of Single-Walled Carbon Nanotubes through Enzymatic Catalysis.  Nano Lett. 2008 Nov;8(11):3899-903. Epub 2008 Oct 28.  PMID: 18954125

  14. Kagan VE, Bayir A, Bayir H, Stoyanovsky D, Borisenko GG, Tyurina YY, Wipf P, Atkinson J, Greenberger JS, Chapkin RS, Belikova NA.  Mitochondria-targeted disruptors and inhibitors of cytochrome c/cardiolipin peroxidase complexes: A new strategy in anti-apoptotic drug discovery.  Mol Nutr Food Res. 2008 Oct 31.   PMID: 18979502

  15. Tyurin VA, Tyurina YY, Feng W, Mnuskin A, Jiang J, Tang M, Zhang X, Zhao Q, Kochanek PM, Clark RS, Bayır H, Kagan VE.  Mass-Spectrometric Characterization of Phospholipids and their Primary Peroxidation Products in Rat Cortical Neurons During Staurosporine-Induced Apoptosis.  J Neurochem. 2008 Nov 6. PMID: 19014376

  16. Du L, Hickey RW, Bayir H, Watkins SC, Tyurin VA, Guo F, Kochanek PM, Jenkins LW, Ren J, Gibson G, Chu CT, Kagan VE, Clark RS.  Starving Neurons Show Sex Difference in Autophagy.  J Biol Chem. 2008 Nov 25. PMID: 19036730

  17. Borisenko, G. G. Kapralov, A. A. Tyurin, V. A. Maeda, A. Stoyanovsky, D. A. and Kagan, V. E.  Molecular Design of New Inhibitors of Peroxidase Activity of Cytochrome c/Cardiolipin Complexes: Fluorescent Oxadiazole-Derivatized Cardiolipin.  Biochemistry, November 2008.

  18. Maki RA, Tyurin VA, Lyon RC, Hamilton RL, Dekosky ST, Kagan VE, Reynolds WF. Aberrant expression of myeloperoxidase in astrocytes promotes phospholipid oxidation and memory deficits in a mouse model of Alzheimer's disease.  J Biol Chem. 2008 Dec 5. PMID: 19059911

  19. Jitkaew S, Witasp E, Zhang S, Kagan VE, Fadeel B.  Induction of Caspase- and Reactive Oxygen Species-Independent Phosphatidylserine Externalization in Primary Human Neutrophils: Role in Macrophage Recognition and Engulfment.  J Leukoc Biol. 2008 Dec 23. PMID: 19106181

  20. Bayir H, Adelson PD, Wisniewski SR, Shore P, Lai Y, Brown D, Janesko-Feldman KL, Kagan VE, Kochanek PM.  Therapeutic Hypothermia Preserves Antioxidant Defenses after Severe Traumatic Brain Injury in Infants and Children.  Crit Care Med. 2008 Dec 26.  PMID: 19114918

  21. Godoy LC, Muñoz-Pinedo C, Castro L, Cardaci S, Schonhoff CM, King M, Tórtora V, Marín M, Miao Q, Jiang JF, Kapralov A, Jemmerson R, Silkstone GG, Patel JN, Evans JE, Wilson MT, Green DR, Kagan VE, Radi R, Mannick JB.  Disruption of the M80-Fe Ligation Stimulates the Translocation of Cytochrome C to the Cytoplasm and Nucleus in Nonapoptotic Cells.  Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2653-8. Epub 2009 Feb 5.  PMID: 19196960

  22. Konduru NV, Tyurina YY, Feng W, Basova LV, Belikova NA, Bayir H, Clark K, Rubin M, Stolz D, Vallhov H, Scheynius A, Witasp E, Fadeel B, Kichambare PD, Star A, Kisin ER, Murray AR, Shvedova AA, Kagan VE. Phosphatidylserine Targets Single-walled Carbon Nanotubes to Professional Phagocytes in Vitro and in Vivo.  PLoS ONE. 2009;4(2):e4398. Epub 2009 Feb 9. PMID: 19198650

  23. Shurin MR, Potapovich AI, Tyurina YY, Tourkova IL, Shurin GV, Kagan VE.  Recognition of Live Phosphatidylserine-Labeled Tumor Cells by Dendritic Cells: A Novel Approach to Immunotherapy of Skin Cancer.  Cancer Res. 2009 Mar 10. PMID: 19276376

  24. Kagan VE, Bayır HA, Belikova NA, Kapralov O, Tyurina YY, Tyurin VA, Jiang J, Stoyanovsky DA, Wipf P, Kochanek PM, Greenberger JS, Pitt B, Shvedova AA, Borisenko G.  Cytochrome C/Cardiolipin Relations in Mitochondria: A Kiss of Death.  Free Radic Biol Med. 2009 Mar 11. PMID: 19285551

  25. Murray AR, Kisin E, Leonard SS, Young SH, Kommineni C, Kagan VE, Castranova V, Shvedova AA.  Oxidative Stress and Inflammatory Response in Dermal Toxicity of Single-walled Carbon Nanotubes.  Toxicology. 2009 Mar 29;257(3):161-71. Epub 2008 Dec 30.  PMID: 19150385

  26. Vladimirov VA, Proskurnia EV, Demin EM, Matveeva NS, Lubitskiy OB, Novikov AA, Izmailov DY, Osipov AN, Tikonov VP, Kagan VE.  Dihydroquercetin (taxifolin) and other flavonoids as inhibitors of free radical formation at key stages of apoptosis.  Biochemistry (Mosc), 74(3): 301-7, 2009. PMID: 19364325

  27. Belikova NA, Jiang J, Stoyanovsky DA, Glumac A, Bayir H, Greenberger JS, Kagan VE. Mitochondria-targeted (2-hydroxyamino-vinyl)-triphenyl-phosphonium releases NO* and protects mouse embryonic cells against irradiation-induced apoptosis. FEBS Lett. 2009 May 7. PMID: 19427865

  28. Belikova NA, Tyurina YY, Borisenko G, Tyurin V, Samhan Arias AK, Yanamala N, Furtmüller PG, Klein-Seetharaman J, Obinger C, Kagan VE. Heterolytic reduction of fatty acid hydroperoxides by cytochrome c/cardiolipin complexes: antioxidant function in mitochondria. J Am Chem Soc. 2009 Aug 19;131(32):11288-9. PMID: 19627079

  29. Kagan VE, Wipf P, Stoyanovsky D, Greenberger JS, Borisenko G, Belikova NA, Yanamala N, Samhan Arias AK, Tungekar MA, Jiang J, Tyurina YY, Ji J, Klein-Seetharaman J, Pitt BR, Shvedova AA, Bayır H. Mitochondrial targeting of electron scavenging antioxidants: Regulation of selective oxidation vs random chain reactions. Adv Drug Deliv Rev. 2009 Aug 27. PMID: 19716396

  30. Jiang J, McDonald PR, Dixon TM, Franicola D, Zhang X, Nie S, Epperly LD, Huang Z, Kagan VE, Lazo JS, Epperly MW, Greenberger JS.  Synthetic protection short interfering RNA screen reveals glyburide as a novel radioprotector.  Radiat Res. 2009 Oct;172(4):414-22.  PMID: 19772462

  31. Rajagopalan MS, Gupta K, Epperly MW, Franicola D, Zhang X, Wang H, Zhao H, Tyurin VA, Pierce JG, Kagan VE, Wipf P, Kanai AJ, Greenberger JS. The mitochondria-targeted nitroxide JP4-039 augments potentially lethal irradiation damage repair. In Vivo. 2009 Sep-Oct;23(5):717-26. PMID: 19779106

  32. Tyurina YY, Tyurin VA, Kapralova VI, Amoscato AA, Epperly MW, Greenberger JS, Kagan VE. Mass-spectrometric characterization of phospholipids and their hydroperoxide derivatives in vivo: effects of total body irradiation. Methods Mol Biol. 2009;580:153-83. PMID: 19784599

  33. Belikova NA, Glumac A, Rafikov R, Jiang J, Greenberger JS, Kagan VE, Bayir H. Radioprotection by short-term oxidative preconditioning: Role of manganese superoxide dismutase.  FEBS Lett. 2009 Oct 13. PMID: 19822147.

  34. Sengupta R, Billiar TR, Atkins JL, Kagan VE, Stoyanovsky DA. Nitric oxide and dihydrolipoic acid modulate the activity of caspase 3 in HepG2 cells. FEBS Lett. 2009 Nov 3;583(21):3525-30. Epub 2009 Oct 12. PMID: 19822150

  35. Allen BL, Kotchey GP, Chen Y, Yanamala NV, Klein-Seetharaman J, Kagan VE, Star A. Mechanistic investigations of horseradish peroxidase-catalyzed degradation of single-walled carbon nanotubes. J Am Chem Soc. 2009 Dec 2;131(47):17194-205. PMID: 19891488

  36. Jiang, J, Stoyanovsky DA, Belikova NA, Tyurina YY, Zhao Q, Tungekar MA, Kapralova V, Huang Z, Mintz AH, Greenberger JS, Kagan VE. A Mitochondria-Targeted Triphenylphosphonium-Conjugated Nitroxide Functions as a Radioprotector/Mitigator. Radiat. Res. 2009 Dec; 172(6): 706-717. PMID: 19929417

  37. Tyurin VA, Tyurina YY, Ritov VB, Lysytsya A, Amoscato AA, Kochanek PM, Hamilton R, Dekosky ST, Greenberger JS, Bayir H, Kagan VE. Oxidative lipidomics of apoptosis: quantitative assessment of phospholipid hydroperoxides in cells and tissues. Methods Mol Biol. 2010;610:353-74. PubMed PMID: 20013189

  38. Sengupta R, Billiar TR, Kagan VE, Stoyanovsky DA. Nitric oxide and thioredoxin type 1 modulate the activity of caspase 8 in HepG2 cells. Biochem Biophys Res Commun. 2010 Jan 1;391(1):1127-30. Epub 2009 Dec 11. PMID: 20005201

  39. Hilmi IA, Peng Z, Planinsic RM, Damian D, Dai F, Tyurina YY, Kagan VE, Kellum JA. N-acetylcysteine does not prevent hepatorenal ischaemia-reperfusion injury in patients undergoing orthotopic liver transplantation. Nephrol Dial Transplant. 2010 Feb 22. PMID: 20179007

  40. Kagan VE, Konduru NV, Feng W, Allen BL, Conroy J, Volkov Y, Vlasova II, Belikova NA, Yanamala N, Kapralov A, Tyurina YY, Shi J, Kisin ER, Murray AR, Franks J, Stolz D, Gou P, Klein-Seetharaman J, Fadeel B, Star A, Shvedova AA. Carbon nanotubes degraded by neutrophil myeloperoxidase induce less pulmonary inflammation. Nat Nanotechnol. 2010 Apr 4. PMID: 20364135

  41. Li W, Wu S, Ahmad M, Jiang J, Liu H, Nagayama T, Rose ME, Tyurin VA, Tyurina YY, Borisenko GG, Belikova N, Chen J, Kagan VE, Graham SH. The Cyclooxygenase Site, But Not the Peroxidase Site of Cyclooxygenase-2 is required for Neurotoxicity in Hypoxic and Ischemic Injury. J Neurochem, 2010

  42. Shvedova AA, Kagan VE. The role of Nanotoxicology in realizing the ‘helping without harm’ paradigm of nanomedicine: lessons from studies of pulmonary effects of single-walled carbon nanotubes. J Intern Med, 267(1):106-18, 2010

  43. Shvedova AA, Kagan VE, Fadeel B. Close encounters of the small kind: adverse effects of man-made materials interfacing with the nano-cosmos of biological systems. Annu Rev Pharmacol Toxicol. 20:63-88, 2010, Review

  44. Stoyanovsky DA, Kapralov A, Huang Z, Maeda A, Osipov A, Hsia CJ, Ma L, Kochanek PM, Bayir H, Kagan VE. Unusual Peroxidase Activity of Polynitroxylated Pegylated Hemoglobin: Elimination of H2O2 Coupled with Intramolecular Oxidation of Nitroxides. Biochem Biophys Res Commun. 2010 Jul 16. PMID: 20643098

  45. Kagan VE, Shi J, Feng W, Shvedova AA, Fadeel B. Fantastic voyage and opportunities of engineered nanomaterials: What are the potential risks of occupational exposures? J Occup Environ Med. 2010 Sep;52(9):943-946. PubMed PMID: 20829674

  46. Huang Z, Jiang J, Belikova NA, Stoyanovsky DA, Kagan VE, Mintz AH. Protection of normal brain cells from γ-irradiation-induced apoptosis by a mitochondria-targeted triphenyl-phosphonium-nitroxide: a possible utility in glioblastoma therapy. J Neurooncol. 2010 Oct;100(1):1-8. Epub 2010 Sep 12. PubMed PMID: 20835910

  47. Walson KH, Tang M, Glumac A, Alexander H, Manole MD, Ma L, Hsia CJ, Clark RS, Kochanek PM, Kagan VE, Bayir H. Normoxic versus hyperoxic resuscitation in pediatric asphyxial cardiac arrest: Effects on oxidative stress. Crit Care Med. 2010 Nov 4. PubMed PMID: 21057313

  48. Vlasova II, Feng WH, Goff JP, Giorgianni A, Do D, Gollin SM, Lewis DW, Kagan VE, Yalowich JC. Myeloperoxidase-dependent oxidation of etoposide in human myeloid progenitor CD34+ cells. Mol Pharmacol. 2011 Mar;79(3):479-87. Epub 2010 Nov 19. PubMed PMID: 21097707; PubMed Central PMCID: PMC3061368

  49. Li HH, Xu J, Wasserloos KJ, Li J, Tyurina YY, Kagan VE, Wang X, Chen AF, Liu ZQ, Stoyanovsky D, Pitt BR, Zhang LM. Cytoprotective effects of Albumin, Nitrosated or Reduced, in Cultured Rat Pulmonary Vascular Cells. Am J Physiol Lung Cell Mol Physiol. 2011 Jan 14. PMID: 21239532

  50. Thambiayya K, Wasserloos KJ, Huang Z, Kagan VE, St Croix CM, Pitt BR. LPS-induced decrease in intracellular labile zinc [Zni] contributes to apoptosis in cultured sheep pulmonary artery endothelial cells (SPAEC). Am J Physiol Lung Cell Mol Physiol. 2011 Jan 14. PMID: 21239534

  51. Samhan-Arias AK, Tyurina YY, Kagan VE. Lipid antioxidants: free radical scavenging versus regulation of enzymatic lipid peroxidation. J Clin Biochem Nutr. 2011 Jan;48(1):91-5. Epub 2010 Dec 28. PubMed PMID: 21297919

  52. Tyurina YY, Tyurin VA, Kapralova VI, Wasserloos K, Mosher M, Epperly MW, Greenberger JS, Pitt BR, Kagan VE. Oxidative lipidomics of ϒ-radiation-induced lung injury: mass spectrometric characterization of cardiolipin and phosphatidylserine peroxidation. Radiat Res. 2011 May;175(5):610-21. Epub 2011 Feb 21. PMID:21338246

  53. Kapralov AA, Yanamala N, Tyurina YY, Castro L, Arias AS, Vladimirov YA, Maeda A, Weitz AA, Peterson J, Mylnikov D, Demicheli V, Tortora V, Klein-Seetharaman J, Radi R, Kagan VE. Topography of tyrosine residues and their involvement in peroxidation of polyunsaturated cardiolipin in cytochrome c/cardiolipin peroxidase complexes. Biochim Biophys Acta. 2011 Sep;1808(9):2147-55. Epub 2011 Apr 29. PubMed PMID: 21550335

  54. Stoyanovsky, D. A., Maeda, A., Atkins, J. L., and Kagan, V. E. (2011) Assessments of Thiyl Radicals in Biosystems: Difficulties and New Applications, Anal Chem. 2011 Jun 1. PMID:21591751

  55. Jiang J, Maeda A, Ji J, Baty CJ, Watkins SC, Greenberger JS, Kagan VE. Are mitochondrial reactive oxygen species required for autophagy? Biochem Biophys Res Commun. 2011 Aug 19;412(1):55-60. Epub 2011 Jul 22. PubMed PMID: 21806968

  56. Belikova NA, Glumac AL, Kapralova V, Cheikhi A, Tyurina YY, Vagni VA, Kochanek PM, Kagan VE, Bayîr H. A high-throughput screening assay of ascorbate in brain samples. J Neurosci Methods. 2011 Aug 9. PubMed PMID: 21855575

  57. Tyurin VA, Cao W, Tyurina YY, Gabrilovich DI, Kagan VE. Mass-spectrometric characterization of peroxidized and hydrolyzed lipids in plasma and dendritic cells of tumor-bearing animals. Biochem Biophys Res Commun. 2011 Sep 16;413(1):149-53. Epub 2011 Aug 22. PubMed PMID: 21872574

  58. Atkinson J, Kapralov AA, Yanamala N, Tyurina YY, Amoscato AA, Pearce L, Peterson J, Huang Z, Jiang J, Samhan-Arias AK, Maeda A, Feng W, Wasserloos K, Belikova NA, Tyurin VA, Wang H, Fletcher J, Wang Y, Vlasova II, Klein-Seetharaman J, Stoyanovsky DA, Bayîr H, Pitt BR, Epperly MW, Greenberger JS, Kagan VE. A mitochondria-targeted inhibitor of cytochrome c peroxidase mitigates radiation-induced death. Nat Commun. 2011 Oct 11;2:497. doi: 10.1038/ncomms1499. PubMed PMID: 21988913

  59. Ji J, Tyurina YY, Tang M, Feng W, Stolz DB, Clark RS, Meaney DF, Kochanek PM, Kagan VE, Bayîr H. Mitochondrial Injury after Mechanical Stretch of Cortical Neurons in Vitro: Biomarkers of Apoptosis and Selective Peroxidation of Anionic Phospholipids. J Neurotrauma. 2011 Nov 4. PubMed PMID: 21895519

  60. Tyurina YY, Tungekar MA, Jung MY, Tyurin VA, Greenberger JS, Stoyanovsky DA, Kagan VE. Mitochondria targeting of non-peroxidizable triphenylphosphonium conjugated oleic acid protects mouse embryonic cells against apoptosis: Role of cardiolipin remodeling. FEBS Lett. 2011 Dec 28. PubMed PMID: 22210054

  61. Stoyanovsky DA, Huang Z, Jiang J, Belikova NA, Tyurin V, Epperly MW, Greenberger JS, Bayir H, Kagan VE. A manganese-porphyrin complex decomposes H2O2, inhibits apoptosis, and acts as a radiation mitigator in vivo. ACS Med Chem Lett. 2011 Nov 10;2(11):814-817. PubMed PMID: 22247787

  62. Midwinter RG, Maghzal GJ, Dennis JM, Wu BJ, Cai H, Kapralov AA, Belikova NA, Tyurina YY, Dong LF, Khachigian L, Neuzil J, Kagan VE, Stocker R. Succinobucol induces apoptosis in vascular smooth muscle cells. Free Radic Biol Med. 2012 Mar 1;52(5):871-9. Epub 2011 Dec 21. PMID: 22203369

  63. Samhan-Arias AK, Ji J, Demidova OM, Sparvero LJ, Feng W, Tyurin V, Tyurina YY, Epperly MW, Shvedova AA, Greenberger JS, Bayir H, Kagan VE, Amoscato AA. Oxidized phospholipids as biomarkers of tissue and cell damage with a focus on cardiolipin. Biochim Biophys Acta. 2012 Mar 23. PMID: 22464971

  64. Shi J, Karlsson HL, Johansson K, Gogvadze V, Xiao L, Li J, Burks T, Garcia-Bennett A, Uheida A, Muhammed M, Mathur S, Morgenstern R, Kagan VE, Fadeel B. Microsomal glutathione transferase 1 protects against toxicity induced by silica nanoparticles but not by zinc oxide nanoparticles. ACS Nano. 2012 Mar 27;6(3):1925-38. Epub 2012 Feb 13. PMID:22303956

  65. Kapralov AA, Feng WH, Amoscato AA, Yanamala N, Balasubramanian K, Winnica DE, Kisin ER, Kotchey GP, Gou P, Sparvero LJ, Ray P, Mallampalli RK, Klein-Seetharaman J, Fadeel B, Star A, Shvedova AA, Kagan VE. Selective Adsorption of Surfactant Lipids by Single-Walled Carbon Nanotubes in Mouse Lung upon Pharyngeal Aspiration: Role in Uptake by Macrophages. ACS Nano. 2012 Apr 1. PMID: 22463369

  66. Shvedova AA, Kapralov AA, Feng WH, Kisin ER, Murray AR, Mercer RR, St Croix CM, Lang MA, Watkins SC, Konduru NV, Allen BL, Conroy J, Kotchey GP, Mohamed BM, Meade AD, Volkov Y, Star A, Fadeel B, Kagan VE. Impaired clearance and enhanced pulmonary inflammatory/fibrotic response to carbon nanotubes in myeloperoxidase-deficient mice. PLoS One. 2012;7(3):e30923. Epub 2012 Mar 30. PMID: 22479306

  67. Shvedova AA, Pietroiusti A, Fadeel B, Kagan VE. Mechanisms of carbon nanotube-induced toxicity: Focus on oxidative stress. Toxicol Appl Pharmacol. 2012 Apr 6. PMID: 22513272

  68. Murray AR, Kisin ER, Tkach AV, Yanamala N, Mercer RR, Young SH, Fadeel B, Kagan VE, Shvedova AA. Factoring-in agglomeration of carbon nanotubes and nanofibers for better prediction of their toxicity versus asbestos. Part Fibre Toxicol. 2012 Apr 10;9(1):10. PMID: 22490147

  69. Thambiayya K, Wasserloos KJ, Kagan VE, Stoyanovsky D, Pitt BR. A critical role for increased labile zinc in reducing sensitivity of cultured sheep pulmonary artery endothelial cells to LPS-induced apoptosis. Am J Physiol Lung Cell Mol Physiol. 2012 Apr 20. PMID: 22523284

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