Principal Investigator: Wei Chen, Ph.D.


I am an Associate Professor of Pediatrics (primary, with Tenure), Biostatistics (secondary), Human Genetics (secondary), and Biomedical Informatics (secondary) at the University of Pittsburgh and the Director of Statistical Genetics Core at UPMC Children's Hospital of Pittsburgh. My lab is interested in the development of statistical and computational methods for high-throughput genetic/genomic data (e.g. next-generation sequencing, methylation, RNA-seq data, and single cell sequencing) and the genetic study of complex diseases, including age-related macular degeneration (AMD), childhood asthma, and chronic obstructive pulumonary disease (COPD). Our lab is currently supported by the University of Pittsburgh, National Eye Institute (NEI), National Human Genome Research Institute (NHGRI), and National Heart, Lung, and Blood Institute (NHLBI). A research summary can be found here. We are actively looking for local and distant collaborations.

Postdoc positions are available here. Positions for graduate student research assistants and undergraduate student workers are also available. Rotation students are also welcome. Please contact Wei Chen at for more information.

Recent News

  • 4/2020 Tao Sun was inducted to the Delta Omega Honor Society, which is a renewed national honorary society (founded in 1924) in the field of public health
  • 3/2020 Zhe Sun was nominated Outstanding Student Award from Graduate School of Public Health (GSPH)
  • 3/2020 Yue Wei won the Honorable Mentions for the oral presentation in the Annual Biostatistics Research Day
  • 3/2020 Tao Sun won the Best Presentation Award in the Annual Biostatistics Research Day
  • 11/2019 Tao Sun received a Travel Award at the MD Anderson Cancer Center to attend the Integrative Biostatistics Research for Imaging, Genomics and High-throughput Technologies in Precision Medicine (iBRIGHT) conference
  • 7/2019 Xinjun Wang, with Dr. Wei Chen, awarded CTSI QuMP Pilots Funding, an NIH grant, from University of Pittsburgh
  • 6/2019 Tao Sun received a Travel Award for the Deep Learning Workshop hosted by the Statistical and Applied Mathematical Sciences Institute (SAMSI)
  • 5/2019 Tao Sun received the Lifetime Data Science Conference (LiDS) 2019 Best Poster Award
  • 4/2019 Tao Sun received the Outstanding Teaching Assistant Award for being a primary instructor in the Department of Biostatistics during both 2017 and 2018 academic years
  • More
  • Recent Publications

  • 5/2020 Our collaboration work (Tao Sun and Jianjiao Chen) on single-cell RNAseq and immunology was incorporated into a milestone paper and was published in Science
  • 5/2020 Xinjun Wang and Zhe Sun’s single cell joint clustering paper was published in Nucleic Acids Research
  • 4/2020 Dr. Soyeon Kim’s work on SNPs identified by GWAS affect asthma risk through DNA methylation and expression of cis-genes in airway epithelium was published in European Respiratory Journal
  • 4/2020 Tao Sun’s comprehensive R package CopulaCenR paper was accepted by the R Journal
  • 2/2020 Our collaborative work (Rong Zhang, Yale Jiang, Drs. Soyeon Kim and Qi Yan) with Drs. Forno and Celedon was published in in The Journal of Allergy and Clinical Immunology
  • 2/2020 Dr. Qi Yan’s deep learning prediction of AMD progression paper was published in Nature Machine Intelligence
  • 11/2019 Tao Sun’s first-author biomedical paper with Dr. Jay Kolls and Dr. Kong Chen, investigating transcriptomic responses to drug Ivacaftor as well as predicting good cynical responders to this drug, was published with an editorial highlight in The American Journal of Respiratory Cell and Molecular Biology
  • 10/2019 Yue Wei and Yi Liu’s functional regression with bivariate time-to-event data paper was published in Biometrics
  • 10/2019 Ge Yang’s clinical paper, Sleep duration, current asthma, and lung function in a nationwide study of U.S. adults, was published in American Journal of Respiratory and Critical Care Medicine
  • 9/2019 Tao Sun’s methodology paper on a novel copula-based semiparametric transformation model for bivariate interval-censored data was published online in Biostatisticseing a primary instructor in the Department of Biostatistics during both 2017 and 2018 academic years
  • More