A number of years ago, this change suggested to a number of folks that perhaps preeclampsia can as an important target. The idea was that maybe the kind of heterogeneity of preeclampsia, multiple organ involvement, could have as a common underlying target. There was some evidence to support that at the time. I mentioned the kidney changes but I also mentioned that those changes that suggested it were the kind of things you might expect if you didn’t have adequate endothelial vasodilators. This has been supported by taking vessels from preeclamptic women, hanging them up in the bath, and they have reduced endothelial relaxation. So the story can be pretty well supported. It’s been about ten years and now there’s probably a list that would no longer fit on this slide of markers of endothelial activation with the disease, with several of these present before the woman is sick. The concept of endothelial disease is not because of high blood pressure, is not because of vaso-constriction, but it’s the endothelial changes that bring about the other changes.