If you go from pathology to pathophysiology, you find that there’s a reduction of blood flow to virtually all of the organs of the preeclamptic woman: not just her uterus, but her brain, her liver, her kidneys. That’s due to increased sensitivity to pressors. The blood pressure increase and the narrowing of blood vessels are not because of mysterious toxins or even increased concentrations of usual pressors, but because the vessels are exquisitely sensitive to any agent you administer. In addition to vasoconstriction, you can demonstrate activation of coagulation cascade, which is going to suggest that the women are clotting their blood in vivo, and those little clots further compromise blood flow. Then, the perfusion is reduced because fluid leaks out of the vascular compartment, again, a further compromise of perfusion.