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In 1995, the World Health Assembly called for a reassessment of the Health-for-All Strategy, to culminate in a Renewal Strategy . Various trends have made renewal necessary, including globalization of trade, travel and technology, urbanization and the growth of megacities, widening gaps between the rich and poor, changing concepts of health, the rise of non-communicable diseases, environmental threats, and expanded scientific and technical knowledge. The new strategy will work on incorporating forecasts of future trends in disease burden in policy-making and forward planning. More accurate estimation of future disease burdens will therefore be needed. This in turn will demand a more comprehensive understanding of health determinants, including the complex interactions between socioeconomic, environmental, demographic and macropolitical and health sector determinants.