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front |1 |2 |3 |4 |5 |6 |7 |8 |9 |10 |11 |12 |13 |14 |15 |16 |17 |18 |19 |20 |21 |22 |23 |24 |25 |26 |27 |28 |review |
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Activation of D2
receptor inhibits adenylate cyclase and, decreases of cAMP, also – activates K+ channels
and inhibit polyphosphoinositide turnover. D1 are most abundant in striatum, limbic system, thalamus and hypothalamus, D2 - in striatum, limbic system, thalamus and hypothalamus and pituitary gland, D3 – in limbic system, but not in the striatum, D4- is much more weakly expressed, mainly in the cortex and limbic system. The functions of DA-ergic pathways divide into: - Motor control ( nigrostriatal system) - Behavioral effects (mesolimbic and mesocortical system) - Endocrine control (tuberohypophyseal system). |