Peer Review Articles (since 2007)

1. Samhan-Arias AK, Ji J, Demidova OM, Sparvero LJ, Feng W, Tyurin V, Tyurina YY, Epperly MW, Shvedova AA, Greenberger JS, Bayır H, Kagan VE, Amoscato AA. Oxidized phospholipids as biomarkers of tissue and cell damage with a focus on cardiolipin. Biochim Biophys Acta. 2012 Mar 23. PMID: 22464971
2. Tyurina YY, Tungekar MA, Jung MY, Tyurin VA, Greenberger JS, Stoyanovsky DA, Kagan VE. Mitochondria targeting of non-peroxidizable triphenylphosphonium conjugated oleic acid protects mouse embryonic cells against apoptosis: role of cardiolipin remodeling. FEBS Lett. 2012 Feb 3;586(3):235-41. PMCID: PMC3273856. PMID: 22210054
   
3. Midwinter RG, Maghzal GJ, Dennis JM, Wu BJ, Cai H, Kapralov AA, Belikova NA, Tyurina YY, Dong LF, Khachigian L, Neuzil J, Kagan VE, Stocker R. Succinobucol induces apoptosis in vascular smooth muscle cells. Free Radic Biol Med. 2012 Mar 1;52(5):871-9. PMID:22203369. PMID: 22203369
4. Atkinson J, Kapralov AA, Yanamala N, Tyurina YY, Amoscato AA, Pearce L, Peterson J, Huang Z, Jiang J, Samhan-Arias AK, Maeda A, Feng W, Wasserloos K, Belikova NA, Tyurin VA, Wang H, Fletcher J, Wang Y, Vlasova II, Klein-Seetharaman J, Stoyanovsky DA, Bayîr H, Pitt BR, Epperly MW, Greenberger JS, Kagan VE. A mitochondria-targeted inhibitor of cytochrome c peroxidase mitigates radiation-induced death. Nat Commun. 2011 Oct 11;2:497. doi: 10.1038/ncomms1499. PMID: 21988913
   
5. Ji J, Tyurina YY, Tang M, Feng W, Stolz DB, Clark RS, Meaney DF, Kochanek PM, Kagan VE, Bayır H. Mitochondrial injury after mechanical stretch of cortical neurons in vitro: biomarkers of apoptosis and selective peroxidation of anionic phospholipids. J Neurotrauma. 2012; 29(5):776-88, PMCID:PMC3303096. PMID: 21895519
6. Tyurin VA, Cao W, Tyurina YY, Gabrilovich DI, Kagan VE. Mass-spectrometric characterization of peroxidized and hydrolyzed lipids in plasma and dendritic cells of tumor-bearing animals. Biochem Biophys Res Commun. 2011; 413(1):149-53. PMCID: PMC3356782. PMID: 21872574
7. Belikova NA, Glumac AL, Kapralova V, Cheikhi A, Tyurina YY, Vagni VA, Kochanek PM, Kagan VE, Bayir H. A high-throughput screening assay of ascorbate in brain samples. J Neurosci Methods. 2011; 201(1):185-90. PMCID: PMC3276367. PMID: 21855575
8. Tyurina YY, Kisin ER, Murray A, Tyurin VA, Kapralova VI, Sparvero LJ, Amoscato AA, Samhan-Arias AK, Swedin L, Lahesmaa R, Fadeel B, Shvedova AA, Kagan VE. Global phospholipidomics analysis reveals selective pulmonary peroxidation profiles upon inhalation of single-walled carbon nanotubes. ACS Nano. 2011;5(9):7342-53. PMCID:PMC3321726
   
9. Kapralov AA, Yanamala N, Tyurina YY, Castro L, Arias AS, Vladimirov YA, Maeda A, Weitz AA, Peterson J, Mylnikov D, Demicheli V, Tortora V, Klein-Seetharaman J, Radi R, Kagan VE. Topography of tyrosine residues and their involvement in peroxidation of polyunsaturated cardiolipin in cytochrome c/cardiolipin peroxidase complexes. Biochim Biophys Acta. 2011; 1808(9):2147-55; PMCID:PMC3321730. PMID: 21550335
   
10. Rwigema JC, Beck B, Wang W, Doemling A, Epperly MW, Shields D, Goff JP, Franicola D, Dixon T, Frantz MC, Wipf P, Tyurina YY, Kagan VE, Wang H, Greenberger JS. Two Strategies for the Development of Mitochondrion-targeted Small Molecule Radiation Damage Mitigators. Int J Radiat Oncol Biol Phys. 2011, 80(3):860-8. PMID: 21493014.
    
11. Tyurina YY, Tyurin VA, Kapralova VI, Wasserloos KJ, Mosher M, Epperlty M, Greenberger JS, Pitt BR, Kagan VE. Oxidative lipidomics of gamma-irradiationinduced lung injury: Mass spectrometric characterization of cardiolipin and phosphatidylserine peroxidation. Radiat. Res. 2011, 175(5):610-621. PMID: 21338246. PMID:21338246
12. Kotchey GP, Allen BL, Vedala H, Yanamala N, Kapralov AA, Tyurina YY, Klein-Seetharaman J, Kagan VE, Star A. The Enzymatic Oxidation of Graphene Oxide. ACS Nano. 2011, 5(3):2098-108. PMID: 21344859
    
13. Samhan-Arias AK, Tyurina YY, Kagan VE. Lipid antioxidants: free radical scavenging versus regulation of enzymatic lipid peroxidation. J Clin Biochem Nutr. 2011; 48(1):91-5. PMCID: PMC3022072. PMID: 21297919
14. Li HH, Xu J, Wasserloos KJ, Li J, Tyurina YY, Kagan VE, Wang X, Chen AF, Liu ZQ, Stoyanovsky D, Pitt BR, Zhang LM. Cytoprotective effects of Albumin, Nitrosated or Reduced, in Cultured Rat Pulmonary Vascular Cells. Am J Physiol Lung Cell Mol Physiol. 2011; 300(4):L526-33. PMCID: PMC3075101 PMID: 21239532
15. Ray NB, Durairaj L, Chen BB, McVerry BJ, Ryan AJ, Donahoe M, Waltenbaugh AK, O'Donnell CP, Henderson FC, Etscheidt CA, McCoy DM, Agassandian M, Hayes-Rowan EC, Coon TA, Butler PL, Gakhar L, Mathur SN, Sieren JC, Tyurina YY, Kagan VE, McLennan G, Mallampalli RK. Dynamic regulation of cardiolipin by the lipid pump Atp8b1 determines the severity of lung injury in experimental pneumonia. Nat Med. 2010; 16(10):1120-7. PMID: 20852622
    
16. Pecina P, Borisenko G, Belikova N, Tyurina Y, Pecinova A, Lee I, Samhan Arias A, Przyklenk K, Kagan V, Huttemann M, Phosphomimetic Substitution of Cytochrome c Tyrosine 48 Decreases Respiration and Binding to Cardiolipin, and Abolishes Ability to Trigger Downstream Caspase Activation, 2010, Biochemistry 2010;49(31):6705-14. PMID: 20586425
    
17. Tyurina YY, Tyurin VA, Kaynar AM, Kapralova VI, Wasserloos KJ, Li J, Mosher M, Wright L, Wipf P, Watkins SK, Pitt BR, Kagan VE. Oxidative lipidomics of hyperoxic acute lung injury: Mass spectrometric characterization of cardiolipin and phosphatidylserine peroxidation. Am J Physiol Lung Cell Mol Physiol. 2010; 299(1):L73-85. PMID: 20418384
    
18. Kagan VE, Konduru NV, Feng W, Allen BL, Conroy J, Volkov Y, Vlasova II, Belikova NA, Yanamala N, Kapralov A, Tyurina YY, Shi J, Kisin ER, Murray AR, Franks J, Stolz D, Gou P, Klein-Seetharaman J, Fadeel B, Star A, Shvedova AA. Carbon nanotubes degraded by neutrophil myeloperoxidase induce less pulmonary inflammation. Nat Nanotechnol. 2010;5(5):354-9. PMID: 20364135
    
19. Li W, Wu S, Ahmad M, Jiang J, Liu H, Nagayama T, Rose ME, Tyurin VA, Tyurina YY, Borisenko GG, Belikova N, Chen J, Kagan VE, Graham SH. The cyclooxygenase site, but not the peroxidase site of cyclooxygenase-2 is required for neurotoxicity in hypoxic and ischemic injury. J Neurochem. 2010 ;113(4):965-77. PMID: 20236388
20. Hilmi IA, Peng Z, Planinsic RM, Damian D, Dai F, Tyurina YY, Kagan VE, Kellum JA. N-acetylcysteine does not prevent hepatorenal ischaemia-reperfusion injury in patients undergoing orthotopic liver transplantation. Nephrol Dial Transplant. 2010; 25(7):2328-33. PMID: 20179007
21. Sanmun D, Witasp E, Jitkaew S, Tyurina YY, Kagan VE, Ahlin A, Palmblad J, Fadeel B. Involvement of a functional NADPH oxidase in neutrophils and macrophages during programmed cell clearance: implications for chronic granulomatous disease. Am J Physiol Cell Physiol. 2009, 297(3):C621-31.PMID: 19570889
    
22. Tyurin VA, Tyurina YY, Ritov VB, Lysytsya A, Amoscato AA, Kochanek PM, Hamilton R, Dekosky ST, Greenberger JS, Bayir H, Kagan VE. Oxidative lipidomics of apoptosis: quantitative assessment of phospholipid hydroperoxides in cells and tissues. Methods Mol Biol. 2010;610:353-74. PMID: 20013189
23. Jiang J, Stoyanovsky DA, Belikova NA, Tyurina YY, Zhao Q, Tungekar MA, Kapralova V, Huang Z, Mintz AH, Greenberger JS, Kagan VE. A mitochondria-targeted triphenylphosphonium-conjugated nitroxide functions as a radioprotector/mitigator. Radiat Res. 2009;172(6):706-17. PMID: 19929417
24. Tyurina YY, Tyurin VA, Kapralova VI, Amoscato AA, Epperly MW, Greenberger JS, Kagan VE. Mass-spectrometric characterization of phospholipids and their hydroperoxide derivatives in vivo: effects of total body irradiation. Methods Mol Biol. 2009;580:153-83. PMID: 19784599
    
25. Belikova NA, Tyurina YY, Borisenko G, Tyurin VA, Samhan Arias AK, Yanamala N, Furtmuller PG, Klein-Seetharaman, Obinger C, Kagan VE. Heterolytic reduction of fatty hydroperoxides by cytochrome c-cardiolipin complexes: antioxidant function in mitochondria. JACS, 2009; 131(32):11288-9. PMID: 19627079
    
26. Bayir H, Kapralov AA, Jiang J, Huang Z, Tyurina YY, Tyurin VA, Zhao Q,Belikova NA, Vlasova II, Maeda A, Zhu J, Na HM, Mastroberardino PG, Sparvero LJ, Amoscato AA, Chu CT, Greenamyre JT, Kagan VE. Peroxidase Mechanism ofLipid-dependent Cross-linking of Synuclein with Cytochrome c: protection against apoptosis vesus delayed oxidative stress in Parkinson disease. J Biol Chem. 2009;284(23):15951-69.
    
27. Tyurin VA, Tyurina YY, Jung MY, Tungekar MA, Wasserloos KJ, Bayır H,Greenberger JS, Kochanek PM, Shvedova AA, Pitt B, Kagan VE. Mass-spectrometricanalysis of hydroperoxy- and hydroxy-derivatives of cardiolipin andphosphatidylserine in cells and tissues induced by pro-apoptotic andpro-inflammatory stimuli. J Chromatogr B Analyt Technol Biomed Life Sci. 2009 877(26):2863-72. PMID: 19328050
    
28. Kagan VE, Bayir HA, Belikova NA, Kapralov O, Tyurina YY, Tyurin VA, Jiang J,Stoyanovsky DA, Wipf P, Kochanek PM, Greenberger JS, Pitt B, Shvedova AA,Borisenko G. Cytochrome c/cardiolipin relations in mitochondria: a kiss of death. Free Radic Biol Med. 2009;46(11):1439-53. PMID: 19285551
29. Shurin MR, Potapovich AI, Tyurina YY, Tourkova IL, Shurin GV, Kagan VE.Recognition of live phosphatidylserine-labeled tumor cells by dendritic cells: a novel approach to immunotherapy of skin cancer. Cancer Res. 2009, 69(6):2487-96. PMID: 19276376
    
30. Konduru NV, Tyurina YY, Feng W, Basova LV, Belikova NA, Bayir H, Clark K, Rubin M, Stolz D, Vallhov H, Scheynius A, Witasp E, Fadeel B, Kichambare PD, StarA, Kisin ER, Murray AR, Shvedova AA, Kagan VE. Phosphatidylserine targetssingle-walled carbon nanotubes to professional phagocytes in vitro and in vivo.PLoS ONE. 2009;4(2):e4398. PMID: 19198650
31. Tyurin VA, Tyurina YY, Kochanek PM, Hamilton R, DeKosky ST, Greenberger JS,Bayir H, Kagan VE. Oxidative lipidomics of programmed cell death. Methods Enzymol. 2008;442:375-93. PMID: 18662580
    
32. Tyurin VA, Tyurina YY, Feng W, Mnuskin A, Jiang J, Tang M, Zhang X, Zhao Q, Kochanek PM, Clark RS, Bayir H, Kagan VE. Mass-spectrometric characterization of phospholipids and their primary peroxidation products in rat cortical neuronsduring staurosporine-induced apoptosis. J Neurochem. 2008;107(6):1614-33. PMID: 19014376
    
33. Kagan VE, Bayir A, Bayir H, Stoyanovsky D, Borisenko GG, Tyurina YY, Wipf P, Atkinson J, Greenberger JS, Chapkin RS, Belikova NA. Mitochondria-targeted disruptors and inhinitors of cytochrome c/cardiolipin peroxidase complexes: A new strategy in anti-apoptotic drug discovery. Mol. Nutr. Food Res. 2008:(1):104-14. PMID: 18979502
    
34. Shvedova AA, Fabisiak JP, Kisin ER, Murray AR, Roberts JR, Tyurina YY, Antonini JM, Feng WH, Kommineni C, Reynolds J, Barchowsky A, Castranova V, Kagan VE. Sequential exposure to carbon nanotubes and bacteria enhances pulmonary inflammation and infectivity. Am J Respir Cell Mol Biol. 200838(5):579-590.
35. Tyurina YY, Tyurin VA, Epperly MF, Greenberger JS, Kagan VE. Oxidative lipidomics of -irradiation induced intestinal injury. Free Radic. Biol. Med. 2008; 44(3):299-314.
    
36. Kapralov AA, Kurnikov IV, Vlasova II, Belikova NA, Tyurin VA, Basova LV, Zhao Q, Tyurina YY, Jiang J, Bayir H, Vladimirov YA, Kagan VE. The hierarchy of structural transitions induced in cytochrome c by anionic phospholipids determines its peroxidase activation and selective peroxidation during apoptosis in cells. Biochemistry. 2007; 46(49):14232-14244.
37. Fink MP, Macias CA, Xiao J, Tyurina YY, Delude RL, Greenberger JS, Kagan VE, Wipf P. Hemigramicidin-TEMPO conjugates: novel mitochondria-targeted antioxidants. Crit Care Med. 2007, 35(9 Suppl):S461-467. PMID: 17713394
    
38. Fink MP, Macias CA, Xiao J, Tyurina YY, Jiang J, Belikova N, Delude RL, Joel S. Greenberger JS, Kagan VE, Wipf P. Hemigramicidin-TEMPO Conjugates: Novel Mitochondria-targeted Anti-oxidants. Biochem. Pharmacol. 2007, 74(6):801-809. PMID: 17601494
    
39. Bayır H, Tyurin VA, Tyurina YY, Viner R, Ritov V, Amoscato AA, Zhao Q, Zhang XJ, Janesko-Feldman KL , Alexander H, Basova L, Clark RSB, Kochanek PM, Kagan VE. Selective Early Cardiolipin Oxidation after Brain Trauma: A Lipidomics Analysis. Annals of Neurology 2007, 62(2):154-169. PMID: 17685468
40. Belikova NA, Jiang, J, Tyurina YY, Zhao Q, Epperly MW, Greenberger J, Kagan VE. Cardiolipin-specific peroxidase reactions of cytochrome c in mitochondria during irradiation induced apoptosis. Int. J. Rad. Oncol. Biol. Phys. 2007, 69(1):176-186. PMID: 17707271
41. Shvedova AA, Kisin R, Murray AR, Gorelik O, Arepalli S, Castranova V, Young SH, Gao F, Tyurina YY, Oury TD, Kagan VE. Vitamin E deficiency enhances pulmonary inflammatory response and oxidative stress induced by single walled carbon nanotubes in C57BL/6 mice. Toxicol. Appl. Physiol. 2007, 221(3):339-348. PMID: 17482224
42. Tyurina YY, Basova LV, Konduru NV, Tyurin VA, Potapovich AI, Cai P, Bayir H, Stoyanovsky D, Pitt BR, Shvedova AA, Fadeel B, Kagan VE. Nitrosative stress inhibits the aminophospholipid translocase resulting in phosphatidylserine externalization and macrophage engulfment: implications for the resolution of inflammation. J Biol Chem. 2007, 282(11):8498-8509. PMID: 17229723
43. Tyurin VA, Tyurina YY, Osipov AN, Belikova NA, Basova LV, Kapralov AA, Bayir H, Kagan VE. Interactions of cardiolipin and lyso-cardiolipins with cytochrome c and tBid: conflict or assistance in apoptosis. Cell Death Differ. 2007, 14(4): 872–875. PMID: 17170752
    
44. Macias CA, Chiao JW, Xiao J, Arora DS, Tyurina YY, Delude RL, Wipf P, Kagan VE, Fink MP. Treatment with a novel hemigramicidin-TEMPO conjugate prolongs survival in a rat model of lethal hemorrhagic shock. Ann Surg. 2007, 245(2):305-314. PMID: 17245186

Books and Book Chapters

1. Kagan VE, Shvedova AA, Tyurina YY. A healthy free radical pessimism. A glance from an oxidative lipidomics conner. In: Mitochondrial Signaling in Health and Disease. (Eds. By Orrenius S., and Cadenas E.) 2012, In press.
2. Fabisiak JP, Tyurina YY, Tyurin VA, Kagan VE. Quantification of selective phosphatidylserine oxidation during apoptosis. Methods Mol Biol. 2005, 291:449-456.
3. Kagan VE, Rao KMK, Kisin ER, Young SH, Meighan T, Murray AR, Tyurina YY, Castranova V, Shvedova AA. Pulmonary effects of sungle-walled carbon nanotubes: Inflammation response, oxidative stress/signaling, and recognition by macrophages. In: Nanotrchnology-Toxicological Issues and Environmental Safety, (P.P. Simeonova et al. (eds.), p.65-75.
4. Tyurina YY, Tyurin VA, Shvedova AA, Fabisiak JP, Kagan VE. Peroxidation of phosphatidylserine in mechanism of apoptotic signaling. Meth. Enzymol. 352: 159-174, 2002.
   
5. Tyurin VA, Tyurina YY, Liu SX, Hubel CA, Bayir H, Kagan VE. Quantitation of S-nitrosothiols in cells and biological fluids. Meth. Enzymol. 352: 347-360, 2002.
   
6. Tyurina YY, Tyurin V, Liu SX, Smith CA, Shvedova AA, Schor NF, Kagan VE. Phosphatidylserine peroxidation during apoptosis: A Signaling Pathway for Phagocyte Clearance by Macrophages. Subcell. Biochem., Vol.36: Phospholipid metabolism in apoptosis. (Eds. By Quinn P., and Kagan V.) Plenum Press, New York, 2002, p.79-96.
   
7. Kagan VE, Fabisiak JP, Tyurina YY. Independent and concerted antioxidant functions of coenzyme Q. Coenzyme Q: from Molecular Mechanisms to Nutrition and Health. (Eds. By Quinn P., and Kagan V.) CRC Press, Boca Raton, London, New York, Washington, D.C., 2000, p.119-130.
   
8. Kagan VE, Tyurina YY, Witt E. Role of coenzyme Q and superoxide in vitamin E cycling. Subcell. Biochem. Vol.30: Fat-Soluble Vitamins (Eds. By Quinn P., and Kagan V.) Plenum Press, New York, 1998, p. 209-217.
   
9. Day BW, Bergamini S, Tyurina YY, Carta G, Tyurin VA, Kagan VE. Beta-carotene: An antioxidant or target of oxidative stress in cells? Subcell. Biochem., Vol.30: Fat-Soluble Vitamins (Eds. By Quinn P., and Kagan V.) Plenum Press, New York, 1998, p. 209-217.
   
10. Kagan VE, Ritov VB, Tyurina YY, Tyurin VA. Sensitive and specific fluorescent probing of oxidative stress in different classes of membrane phospholipids in live cells using metabolically integrated cis-parinaric acid. Meth Mol. Biol. 108 (Free Radical and Antioxidant Protocols, Ed. By Armstrong D.), Humana Press Inc., Totowa, NJ,.1998, pp.71-87.
11. Avrova NF, Tyurin VA, Zakharova IO, Sokolova TV, Tyurina YY. The Effect of glutamate, antioxidants and gangliosides on Na+,K+-ATPase activity in rat brain cortex synaptosomes. Neurochemistry: Cellular, Molecular and Clinical Aspects (Eds. By Tulken A., and Korf J.) - Section 35: Free radicals, NO and brain pathology, Plenum Press, NY. 1997, pp. 973-976.

Invited Articles

1. Samhan-Arias AK, Ji J, Demidova OM, Sparvero LJ, Feng W, Tyurin V, Tyurina YY, Epperly MW, Shvedova AA, Greenberger JS, Bayır H, Kagan VE, Amoscato AA. Oxidized phospholipids as biomarkers of tissue and cell damage with a focus on cardiolipin. Biochim Biophys Acta. 2012 Mar 23. [Epub ahead of print], PMID: 22464971
2. Kagan VE, Bayir HA, Belikova NA, Kapralov O, Tyurina YY, Tyurin VA, Jiang J,Stoyanovsky DA, Wipf P, Kochanek PM, Greenberger JS, Pitt B, Shvedova AA,Borisenko G. Cytochrome c/cardiolipin relations in mitochondria: a kiss of death. Free Radic Biol Med. 2009;46(11):1439-53.
3. Kagan VE, Bayir A, Bayir H, Stoyanovsky D, Borisenko GG, Tyurina YY, Wipf P, Atkinson J, Greenberger JS, Chapkin RS, Belikova NA. Mitochondria-targeted disruptors and inhinitors of cytochrome c/cardiolipin peroxidase complexes: A new strategy in anti-apoptotic drug discovery. Mol. Nutr. Food Res. 2008:1:104-14.
4. Kagan VE, Tyurina YY, Bayir H, Chu CT, Kapralov AA, Vlasova II , Belikova NA, Tyurin VA, Amoscato A, Epperly M, Greenberger J, DeKosky S, Shvedova AA, Jiang J. The "pro-apoptotic genies" get out of mitochondria: Oxidative lipidomics and redox activity of cytochrome c/cardiolipin complexes. Chem. Biol. Interactions 2006, 163(1-2):15-28.
5. Bayir H, Fadeel B, Palladino MJ, Witasp E, Kurnikov IV, Tyurina YY, Tyurin VA, Amoscato AA, Jiang J, Kochanek PM, DeKosky ST, Greenberger JS, Shvedova AA, Kagan VE. Apoptotic interactions of cytochrome c: Redox flirting with anionic phospholipids within and outside of mitochondria Biochim. Biophys. Acta, 2006, 1757(5-6):648-659.
6. Kagan VE, Borisenko GG, Tyurina YY, Tyurin VA, Jiang J, Potapovich AI, Kini V, Amoscato AA, Fujii Y. Oxidative lipidomics of apoptosis: redox catalytic interactions of cytochrome c with cardiolipin and phosphatidylserine. Free Radic Biol Med. 2004, 37:1963-1985.
7. Kagan VE, Borisenko GG, Serinkan BF, Tyurina YY, Tyurin VA, Jiang J, Liu SX, Shvedova AA, Fabisiak JP, Uthaisang W, Fadeel B. Appetizing rancidity of apoptotic cells for macrophages: oxidation, externalization, and recognition of phosphatidylserine. 2003, Am. J Physiol. Lung Cell Mol. Physiol. 285:L1-L17.
8. Kagan VE, Fabisiak JM, Shvedova AA, Tyurina YY, Tyurin VA, Schor NF, Kawai K. Oxidative stress pathway for externalization of plasma membrane phosphatidylserine during apoptosis. FEBS Lett. 2000, 477: 1-7.
9. Kagan VE, Tyurina YY. Recycling and redox cycling of phenolic antioxidant. Ann. New York Acad. Sci. (Towards Prolongation of the Healthy Live Span: Practical Approach to Intervention), 1998, 854: 425-434.
   

Review Articles

1. Kagan VE, Wipf P, Stoyanovsky D, Greenberger JS, Borisenko G, Belikova NA, Yanamala N, Samhan Arias AK, Tungekar MA, Jiang J, Tyurina YY, Ji J, Klein-Seetharaman J, Pitt BR, Shvedova AA, Bayir H. Mitochondrial targeting of electron scavenging antioxidants: Regulation of selective oxidation vs random chain reactions. Adv Drug Deliv Rev. 2009 Nov 30;61(14):1375-85. PMID: 19716396
   
2. Kagan VE, Bayir A, Bayir H, Stoyanovsky D, Borisenko GG, Tyurina YY, Wipf P, Atkinson J, Greenberger JS, Chapkin RS, Belikova NA. Mitochondria-targeted disruptors and inhinitors of cytochrome c/cardiolipin peroxidase complexes: A new strategy in anti-apoptotic drug discovery. Mol. Nutr. Food Res. 2008:(1):104-14.
3. Kagan VE, Tyurina YY, Bayir H, Chu CT, Kapralov AA, Vlasova II , Belikova NA, Tyurin VA, Amoscato A, Epperly M, Greenberger J, DeKosky S, Shvedova AA, Jiang J. The "pro-apoptotic genies" get out of mitochondria: Oxidative lipidomics and redox activity of cytochrome c/cardiolipin complexes. Chem. Biol. Interactions 2006, 163(1-2):15-28.
4. Bayir H, Fadeel B, Palladino MJ, Witasp E, Kurnikov IV, Tyurina YY, Tyurin VA, Amoscato AA, Jiang J, Kochanek PM, DeKosky ST, Greenberger JS, Shvedova AA, Kagan VE. Apoptotic interactions of cytochrome c: Redox flirting with anionic phospholipids within and outside of mitochondria Biochim. Biophys. Acta, 2006, 1757(5-6):648-659.
5. Kagan VE, Borisenko GG, Tyurina YY, Tyurin VA, Jiang J, Potapovich AI, Kini V, Amoscato AA, Fujii Y. Oxidative lipidomics of apoptosis: redox catalytic interactions of cytochrome c with cardiolipin and phosphatidylserine. Free Radic Biol Med. 2004, 37:1963-1985.
6. Kagan VE, Borisenko GG, Serinkan BF, Tyurina YY, Tyurin VA, Jiang J, Liu SX, Shvedova AA, Fabisiak JP, Uthaisang W, Fadeel B. Appetizing rancidity of apoptotic cells for macrophages: oxidation, externalization, and recognition of phosphatidylserine. 2003, Am. J Physiol. Lung Cell Mol. Physiol. 285:L1-L17.
7. Kagan VE, Fabisiak JM, Shvedova AA, Tyurina YY, Tyurin VA, Schor NF, Kawai K. Oxidative stress pathway for externalization of plasma membrane phosphatidylserine during apoptosis. FEBS Lett. 2000, 477: 1-7.
8. Tyurina YY, Shvedova AA, Kawai K, Tyurin VA, Kommineni C, Quinn PJ, Schor NF, Fabisiak JP, Kagan VE. Phospholipid signalling in apoptosis: Peroxidation and externalization of phosphatidylserine. Toxicology 2000, 148: 93-101.
9. Kagan VE, Tyurina YY. Recycling and redox cycling of phenolic antioxidant. Ann. New York Acad. Sci. (Towards Prolongation of the Healthy Live Span: Practical Approach to Intervention), 1998, 854: 425-434.
   

Published Abstracts (since 2007)

1. Tyurina YY, Tungekar MA, Jung MY, Tyurin VA, Stoyanovsky SA, Kagan VE, Mitochondria targeting of non-peroxidizable triphenylphosphonium conjugated oleic acid protects mouse embryonic cells against apoptosis: Role of cardiolipin remodeling. 51th Annual Meeting for Society of Toxicology; The Toxicologist: Suppl. V.126, Suppl. 1, Abstract No. 2035, p.438, March 11-15, 2012, San Francisco CA.
2. Kagan VE, Tyurin VA, Balasubramanian K, Winnica D, Tyurina YY, Macphee CH, Role of oxygenated phosphatidylserine and its metabolitis – lyso-phosphatidylserines produced after oxidation and hydrolysis by plasma lipoprotein-associated phospholipase A2 in clearance of apoptotic cells by macrophages: LC-ESI-MS study. 51th Annual Meeting for Society of Toxicology; The Toxicologist: Suppl. V.126, Suppl. 1, Abstract No. 2056, p.443, March 11-15, 2012, San Francisco CA.
3. Tyurin VA, Zhao H, Tyurina YY, Epperly MW, Greenberger JS, Kagan VE. Monolyso-cardiolipin – biomarker of mitochondrial dysfunction induced by total body irradiation. LC-ESI-MS study. 51th Annual Meeting for Society of Toxicology; The Toxicologist: Suppl. V.126, Suppl. 1, Abstract No. 2034, p.438, March 11-15, 2012, San Francisco CA.
4. Frostegård J., Tyurin VA, Tyurina YY, Amoscato A, Su J, Balasubramanian KK, Maeda A, Fadeel B, Greenberger JS, Mallampali RK, Kagan VE. Interrelationships of peroxidation and immunogenicity of cardiolipin: an oxidative lipidomics approach. 51th Annual Meeting for Society of Toxicology; The Toxicologist: Suppl. V.126, Suppl. 1, Abstract No. 760, p.165, March 11-15, 2012, San Francisco CA.
5. Atkinson J, Kapralov AA, Yanamala N, Tyurina YY, Amoscato AA, Pearce L, Peterson J, Huang Z, Jiang J, Samhan-Arias AK, Maeda A, Feng W, Wasserloos K, Belikova N, Tyurin VA, Wang H, Fletcher J, Wang Y, Vlasova II, Klein-Seetharaman J, Stoyanovsky DA, Bayîr H, Pitt BR, Epperly MW, Greenberger JS, Kagan VE, A mitochondria-targeted imidazole-substituted fatty acids inhibit cytochrome c peroxidase and mitigate radiation induced death. 51th Annual Meeting for Society of Toxicology; The Toxicologist: Suppl. V.126, Suppl. 1, Abstract No. 2036, p.439, March 11-15, 2012, San Francisco CA.
6. Cao W, Tyurin VA, Tyurina YY, Gabrilovich DI, Kagan VE. Oxygenated fatty acids in plasma of tumor-bearing animals stimulate their scavenger receptor A1-mediatd up-take by dendritic cells: Mass-spectrometric evidence. 51th Annual Meeting for Society of Toxicology; The Toxicologist: Suppl. V.126, Suppl. 1, Abstract No. 1624, p.351, March 11-15, 2012, San Francisco CA.
7. Samhan-Arias AK, Tyurin VA, Tyurina YY, Bayır H, Kagan VE, Amoscato AA. 2D-LC-MS analysis of oxidized lipid species: Application to the study of cardiolipin in apoptosis and damaged tissue. 51th Annual Meeting for Society of Toxicology; The Toxicologist: Suppl. V.126, Suppl. 1, Abstract No. 1180, p.254, March 11-15, 2012, San Francisco CA.
8. Amoscato AA, Feng W, Kagan VE, Tyurina YY. Rotenone-induced oxidized molecular species of cardiolipin in human lymphocytes: can they be used as biomarkers of mitochondrial dysfunction associated with Parkinson's disease? 51th Annual Meeting for Society of Toxicology; The Toxicologist: Suppl. V.126, Suppl. 1, Abstract No. 2450, p.528, March 11-15, 2012, San Francisco CA.
9. Tyurin VA, Tyurina YY, Macphee CH, Kagam VE. LC-ESI/MS reveales unusual oxygenated lysophosphatidylserines prodiced after oxidation and hydrolysis by plasma lipoprotein-associated phopsholipase A2 of sn-1, sn-2-2-dilinoleoyl-PS. 50th Annual Meeting for Society of Toxicology; The Toxicologist: Suppl. 2, V.120, Abstract No. 1669, p.359, March 6-10, 2011, Washington DC.
10. Tyurina Y, Tyurin V, Sparvero L, Amoscato A, Kapralova V, Kisin E, Murray A, Shi J, Fadeel B, Shvedova A, Kagan V. Oxidative lipidomics reveals selective, but not random, pulmonary phopsholipid peroxidation after inhalation of carbon nanotubes. 50th Annual Meeting for Society of Toxicology; The Toxicologist: Suppl. 2, V.120, Abstract No. 1170, p.252, March 6-10, 2011, Washington DC.
11. Kagan VE, Tyurin VA, Kapralova V, Kaynar M, Wasserloos K, Mosher M, Wipf, P, Pitt B, Tyurina YY. Oxidative lipidomics of hyperoxia-induced acute lung injury. 49th Annual Meeting for Society of Toxicology; The Toxicologist: Suppl. V.114, No 1, Abstract No. 598, p.128, March 8-11, 2010, Salt Lake City, UT
12. Tyurina YY, Tyurin VA, Kapralova VI, Wasserloos K, Mosher M, Epperly M, Greenberger J, Pitt B, Kagan V. Oxidative lipidomics of gamma-radiation induced lung injury. 49th Annual Meeting for Society of Toxicology; The Toxicologist: Suppl. V.114, No 1, Abstract No. 597, p.128, March 8-11, 2010, Salt Lake City, UT
13. Tyurin VA, Winnica D, Fazzi F, Feng W, Tyurina YY, Stewart NA, Kisin ER, Murray AR, Shvedova AA, Pitt BR, Kagan VE, Ortiz LA. Phospholiopid oxidative metabolism during macrophage response to environmental agents. 49th Annual Meeting for Society of Toxicology; The Toxicologist: Suppl. V.114, No 1, Abstract No. 599, p.128, March 8-11, 2010, Salt Lake City, UT
14. Tyurina YY, Tyurin VA, Kapralova VI, Tungekar MA., Kaynar M, Wasserloos K, Mosher M, Epperly M, Greenberger JS, Pitt BR, Kagan VE. Oxidative lipidomics of acute lung injury induced by hyperoxia and gamma-irradiation. #949, 48th Annual Meeting for Society of Toxicology, Baltimore, 2009.
15. Belikova NA, Jiang J, Kapralova V, Tyurina YY, Greenberger JS, Stoyanovsky DA, Kagan VE. Peroxidase-actvated mitochondria-targeted NO-donor protects mouse embryonic cells against irradiation-induced injury. #1550, 48th Annual Meeting for Society of Toxicology, Baltimore, 2009.
16. Jiang J, Stoyanovsky D, Belikova NA, Zhao Q, Tyurina YY, Tungekar MA, Kapralova V, J.S. Greenberger JS, Kagan VE. Mitochondria-targeted triphenylphosphonium conjugated nitroxide function as a radioprotector. #1549, 48th Annual Meeting for Society of Toxicology, Baltimore, 2009.
17. Feng WH, Tyurin VA, Go K, Tyurina YY, Stewart NAS, Fazzi F, Kisin E, Murray A, Shvedova AA, Pitt BR, Ortiz LA, KaganVE. #936, Oxidative lipidmics of macrophage activation and apoptosis induced by phagocytosis of particles and pathogens. 48th Annual Meeting for Society of Toxicology, Baltimore, 2009.
18. Tyurin VA, Jung MY, Tyurina YY, Prieto T, Zhao Q, Kapralov AA, Belikova NA, Nantes IL, Kagan VE. Cardiolipin oxidation, hydrolysis and accumulation of monolysocardiolipins and oxidized free fatty acids during apoptosis: Role of cytochrome c. #302, 48th Annual Meeting for Society of Toxicology, Baltimore, 2009.
19. Tyurina YY, Wasserloos KJ, Stewart RC, Stitt MS, Kaynar A, Pitt BR, Kagan VE.Oxidative lipidomics of hyperoxic lung injury. 47th Annual Meeteing, Society of Toxicology, Seattle, WA, 2008: The Toxicologist: 1036, p. 213.
20. Feng W, Konduru NV, Tyurina YY, Clark K, Stolz DB, Bayir H, Fadeel B, Shvedova AA, Kagan VE. Involvement of endocytosis in uptake of phosphatidylserine-coated single-walled carbon nanotubes by Rae 264.7 macrophages. 47th Annual Meeteing, Society of Toxicology, Seattle, WA, 2008: The Toxicologist: 2000, p. 411.
21. Feng W, Tyurina YY, Bayir H, Shvedova AA, Kagan VE. Phosphatidylserine functionalization targets single-walled carbon nanotubes to microglial cells. Neuroscience. San Diego, CA, November 3-7, 2007
22. Shvedova AA, Kisin ER, Murray AR, Gorelik O, Arepalli S, Castranova V, Young S.H, Gao F, Tyurina YY, Oury T, Kagan VE. Vitamin E deficiency enhances pulmonary inflammatory response and oxidative stress induced by single walled carbon nanotubes in C57BL/6 mice. 46th Annual Meeteing, Society of Toxicology, Charlotte, NC, 2007: The Toxicologist: 179, p. 37.
23. Kagan VE, Tyurina YY, Konduru N, Basova LV, Stolz D, Kisin ER, Murray AR, Fadeel B, Shvedova AA. Targeted delivery of phosphatidylserine-coated single walled carbon nanotubes to macrophages. 46th Annual Meeteing, Society of Toxicology, Charlotte, NC, 2007: The Toxicologist: 1126, p.223
24. Vlasova II, KapralovAA, Jiang J, Basova LV, Belikova NA, Tyurin VA, Tyurina YY, Martin J, Glumac A, Bayir H, Kagan VE. Peroxidase complexes of cytochrome c with anionic lipids: Structural pre-requisites, mechanism, and cytotoxic effects. 46th Annual Meeteing, Society of Toxicology, Charlotte, NC, 2007: The Toxicologist: 292, p.61.
25. Feng W, Tyurina YY, Bayir H, Shvedova AA, Kagan VE. Phosphatidylserine enhances recognition and uptake of single walled carbon nanotubes by rat brain microglial cells. 46th Annual Meeteing, Society of Toxicology, Charlotte, NC, The Toxicologist, 2007: 1396, p.289.
26. Tyurin VA, Bayir H, Tyurina YY, W. Feng W, Viner R, Amoscato A, Zhao Q, Janesko-Feldman K. Alexander H, Kochanek PM, DeKosky ST, Kagan VE. Mass spectrometric analysis of phospholipid molecular species and their hydroperoxides in apoptotic neurons and injured rat brain. 46th Annual Meeting, Society of Toxicology, Charlotte, NC, The Toxicologist, 2007, p. 39, 187.
27. Belikova NA, Jiang J, Tyurina YY, Zhao Q, Epperly MW, Greenberger J, Kagan VE. Redox regulation of gamma-irradiation induced apoptosis by cytochrome c-cardiolipin complex in HeLa cells. 46th Annual Meeting, Society of Toxicology, Charlotte, NC, The Toxicologist, 2007, p. 61, 291.
28. Tyurina YY, Tyurin VA, Epperly MW, Greenberger JC, Kagan VE. Oxidized cardiolipin as a new biomarker of gamma-irradiation-induced apoptosis. 46th Annual Meeting, Society of Toxicology, Charlotte, NC, The Toxicologist, 2007, p. 61, 294.