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Interactions between Mg2+ and neuromuscular blocking agents are well known, and potential interactions with volatile anesthetic agents have been noted. Few adverse effects have been reported with perioperative administration of Mg2+. Only one study has suggested the possibility of adverse effects of intra-operative use of Mg2+

Concentrations of total Mg2+ higher than the midnormal range were associated with a requirement for more direct current shocks during cardiac defibrillation, but their analysis appears flawed. They initially found no statistically significant differences among groups for the number or energy of direct current shocks needed or for development of ventricular fibrillation after initial spontaneous electrical activity.

Other reported adverse effects of Mg2+ include increased bleeding time.

Mark N. Gomez, MD:Magnesium and Cardiovascular Disease ANESTHESIOLOGY 1998;89:222-240