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Myocardial ischemia is characterised by the swing toward glucose metabolism and disturbances of the cardiac mitochondria metabolism, the most remarkable feature that characterized the cardiac muscle is the stability of the phosphorilation potential in the face of varying workloads, suggesting that several factors are involved in the control of oxidative phosphorylation. Therefore is possible to predict strategies for restoring cardiac mitochondria function under different physiological or pathological conditions.

During myocardial depression or hibernation, the heart will be able to adaptive response to severe chronic hypo perfusion.

In the fully aerobic heart over 90% ATP originates from mitochondria oxidative respiration.

Also important advances over the last two decades, CAD remain a major cause of morbidity and mortality in our society.