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Cancer and normal cells differ in their surface chemistry and functions. Proliferation is improperly regulated by cell-cell contacts, serum factors, etc. Hormone and growth factor receptors are quantitatively and qualitatively modified. Membrane carbohydrates are altered 75 and phospholipid turnover increases.76 Rates of transport of small molecules into cancer cells and into normal cells differ. Again, one finds roots in genetic—environmental miscommunication, here due to imperfect signaling between cells of a multi-cell organism. 77 Many intracellular regulations also are changed. The first proposal for a biochemical basis of cancer made by Otto Warburg was misregulated production of energy (ATP) by glycolysis vs. respiration.78