Wei Chen

Wei Chen

Associate Professor of Pediatrics

University of Pittsburgh

Principal Investigator

My lab focuses on developing statistical and computational methods for the analysis of large-scale biomedical data and applying them to study complex diseases. Collaborating with our colleagues, we use cutting-edge technologies including DNA-seq, RNA-seq, methylation, ATAC-seq and single cell sequencing to study human diseases such as childhood asthma and age-related macular degeneration. Chen lab welcomes collaborators and trainees to move science forward. Our lab is generously supported by National Institute of Health, National Science Foundation, University of Pittsburgh and UPMC.

Recent News

  • 10/2020 Wei Chen received PinCH award to study COVID using mobile health technology
  • 9/2020 Xinjun Wang awarded International Chinese Statistical Association (ICSA) Student Paper Award
  • 8/2020 Wei Chen received R21 for the analysis of omics data in Hispanic asthma kids
  • 7/2020 Wei Chen received R21 for the analysis of imaging and genetic data for age-related macular degeneration
  • 6/2020 Xinjun Wang received RAC Graduate Student Fellowship from UPMC Children’s Hospital of Pittsburgh

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Recent Publications

  • Xin H, Lian Q, Jiang Y, Luo J, Wang X, Erb C, Xu Z, Zhang X, Heidrich-O’Hare E, Yan Q, Duerr RH, Chen K, Chen W. GMM-Demux: sample demultiplexing, multiplet detection, experiment planning, and novel cell-type verification in single cell sequencing. Genome Biol. 2020 Jul 30;21(1):188.

  • Wang X, Sun Z, Zhang Y, Xu Z, Xin H, Huang H, Duerr RH, Chen K, Ding Y, Chen W. BREM-SC: a bayesian random effects mixture model for joint clustering single cell multi-omics data. Nucleic Acids Res. 2020 Jun 19;48(11):5814-5824.

  • Kim S, Forno E, Yan Q, Jiang Y, Zhang R, Boutaoui N, Acosta-Pérez E, Canino G, Chen W, Celedón JC. SNPs identified by GWAS affect asthma risk through DNA methylation and expression of cis-genes in airway epithelium. Eur Respir J. 2020 Apr;55(4).

  • Yan Q, Weeks DE, Xin H, Swaroop A, Chew EY, Huang H, Ding Y, Chen W. Deep-learning-based Prediction of Late Age-Related Macular Degeneration Progression. Nat Mach Intell. 2020 Feb;2(2):141-150.

  • Sun Z, Chen L, Xin H, Jiang Y, Huang Q, Cillo AR, Tabib T, Kolls JK, Bruno TC, Lafyatis R, Vignali DAA, Chen K, Ding Y, Hu M, Chen W. A Bayesian mixture model for clustering droplet-based single-cell transcriptomic data from population studies. Nat Commun. 2019 Apr 9;10(1):1649.

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