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新近问世的药物对众多酒精依赖患者有效。研究指出寻求酒精的行为受多种神经递质系统的影响:神经调节因子、激素以及细胞间信号传递网络。这些都可成为新药物的靶点。潜在的靶点位置包括:神经递质系统( opioids, serotonin, dopamine, glutamate, gamma-aminobutyric acid (GABA), cannabinoids, the hypothalamic-pituitary-adrenal (HPA) axis, adenosine),神经肽系统( neuropeptide Y, corticotrophin releasing factor)信号转导通路(PKA,PKC),以及基因调控因子(delta fos B and cAMP response element-binding protein [CREB]).很多的药物都处于研发状态。