Silvia

Silvia (Shuchang) Liu, Ph.D.

Assistant Professor

Department of Pathology

School of Medicine

University of Pittsburgh


Contact Me:

Email: shl96@pitt.edu

Phone: 412-648-4288

Office: S-406 Biomedical Science Tower, 203 Lothrop Street, Pittsburgh, PA 15261


External Link:

My CV

Linkedin

Google Scholar

Github

Publications


In preparation

  1. Silvia Liu, George C. Tseng*. Meta-analysis of biclustering in high throughput genomics data studies.

  2. Silvia Liu, Wan-Ping Lee*. SVlearning: A flexible platform for integrating structure variation callsets from multiple callers by machine learning algorithms.

  3. Wan-Ping Lee, Qihui Zhu, Silvia Liu, … , CZ Zhang*, Charles Lee*. Development of a Next Generation Sequencing (NGS)-Based Platform for Detection of Copy Number Variations (CNVs) Associated with Constitutional Disorders.

  4. Tianzhou Ma, …, Silvia Liu, …, George Tseng*. MetaOmics: a tool for meta-analysis on omics data. Submitted.

  5. Jian-Hua Luo*, Silvia Liu, ..., Yan-Ping Yu*. Fusion Pten-NOLC1 Promotes C-Met and EGFR Signals in Human Cancers. Submitted.

Published Works

  1. Silvia Liu^, Wei-Hsiang Tsai^, Ying Ding^, Rui Chen, Zhou Fang, SungHwan Kim, Tianzhou Ma, Ting-Yu Chang, Jianhua Luo, Hsei-Wei Wang*, I-Fang Chung* and George C. Tseng*. Comprehensive evaluation of fusion transcript detection algorithms and a meta-caller to combine top performing methods in paired-end RNA-seq data. Nucleic Acids Research. 2016. (Link) (FusionMetaCaller: an R package to combine results of multiple top-performing fusion transcript detection algorithms from paired-end RNA-seq data) (PubMed ID: 26582927)

  2. Zhiguang Huo, Ying Ding, Silvia Liu, Steffi Oesterreich*, George C. Tseng*. Meta-analytic framework for sparse K-means to identify disease subtypes in multiple transcriptomic studies. Journal of the American Statistical Association. Journal of the American Statistical Association. 2015. (Link)

  3. Yan-Bing Qi, Xiao-Lei Wang, Ting Shi, Shuchang Liu, Zhen-Hao Xu, Xiqing Li, Xuling Shi, Ping Xu, and Yi-Lei Zhao*. Multicomponent kinetic analysis and theoretical studies on the phenolic intermediates in the oxidation of eugenol and isoeugenol catalyzed by laccase. Physical Chemistry Chemical Physics 17, no. 44 (2015): 29597-29607. (Link) (PubMed ID: 26477512)

  4. Yan P. Yu^, Silvia Liu^, Zhigang Huo, Amantha Martin, Joel B. Nelson, George C. Tseng and Jian-Hua Luo. Genomic copy number variations in the genomes of leukocytes predict prostate cancer clinical outcomes. PLoS ONE 2015 Aug 21; 10(8): e0135982. (Link) (PubMed ID: 26295840)

  5. Jian-Hua Luo*, Silvia Liu, Ze-Hua Zuo, Rui Chen, George C. Tseng*, Yan P. Yu*. Discovery and Classification of Fusion Transcripts in Prostate Cancer and Normal Prostate Tissue. The American Journal of Pathology. Available online 9 May 2015, ISSN 0002-9440, http://dx.doi.org/10.1016/j.ajpath.2015.03.008.(Link) (PubMed ID: 25963990)

  6. Lin Wang^, Silvia Liu^, Ying Ding, Shin-sheng Yuan , Yen-Yi Ho*, and George C. Tseng*. Meta-analytic framework for liquid association. Bioinformatics. (2017). (Link) (PubMed ID: 28334340)

  7. Ze-Hua Zuo, Yan P. Yu, Ying Ding, Silvia Liu, Amantha Martin, George Tseng*, Jian-Hua Luo*. Oncogenic Activity of miRNA 650 in Prostate Cancer Is Mediated by Suppression of CSR1 Expression. The American Journal of Pathology. Available online 5 May 2015, ISSN 0002-9440, http://dx.doi.org/10.1016/j.ajpath.2015.03.015. (Link) (PubMed ID: 25956032)

  8. Yan P. Yu^*, Ying Ding^, Zhanghui Chen^, Silvia Liu, Amantha Michalopoulos, Rui Chen, Zulfiqar G. Gulzar, Bing Yang, Kathleen M. Cieply, Alyssa Luvison, Bao-Guo Ren, James D. Brooks, David Jarrard, Joel B. Nelson*, George K. Michalopoulos, George C. Tseng*, Jian-Hua Luo*. Novel Fusion Transcripts Associate with Progressive Prostate Cancer. The American Journal of Pathology. Volume 184, Issue 10, October 2014, Pages 2840-2849, ISSN 0002-9440, http://dx.doi.org/10.1016/j.ajpath.2014.06.025. (Link) (PubMed ID: 25238935)

  9. Shirish Paranjpe, ..., Silvia Liu, George C.Tseng, George K. Michalopoulos. Combined systemic elimination of MET and EGFR signaling completely abolishes liver regeneration and leads to liver decompensation. Hepatology. 2016. (Link) (PubMed ID: 27397846)

  10. Zhang-hui Chen, ..., Silvia Liu, ..., Jian-Hua Luo*. MAN2A1–FER Fusion Gene Is Expressed by Human Liver and Other Tumor Types and Has Oncogenic Activity in Mice. Gastroenterology. (2016) (Link) (PubMed ID: 28245430)

  11. D-M He, B-G Ren, S Liu, …, J-H Luo*. Oncogenic Activity of Amplified Miniature Chromosome Maintenance 8 in Human Malignancies. Oncogene, 36 (2017) 3629-3639. (Link) (PubMed ID: 28481876)

  12. Zhang-Hui Chen, …, Silvia Liu, …, Jian-Hua Luo*. Targeting genomic rearrangements in tumor cells using Cas9-mediated insertion of a suicide gene. Nature biotechnology, 35.6 (2017) 543-550. (Link) (PubMed ID: 28459452)

  13. Timothy Becker, ..., Silvia Liu, ..., Charles Lee*, Ankit Malhotra*. FusorSV: An algorithm for optimally combining data from multiple structural variation detection methods. Genome Biology, 19:38 (2018). (Link) (PubMed ID:29559002)

  14. Anne Orr, ..., Silvia Liu, ..., George Michalopoulos*. Combined systemic disruption of MET and EGFR signaling causes liver failure in normal mice. Accepted by The American Journal of Pathology. (2018)

Last Modified: 10/2018