PhD candidate

Department of Biostatistics

University of Pittsburgh

Email: liz86@pitt.edu

Github: lizhu06

I am a 5th year PhD student at George Tseng's group, Department of Biostatistics, University of Pittsburgh. I am also co-mentored by Dr. Steffi Oesterreich and Dr. Adrian Lee at Magee-Women's Research Institute.

Education


Publications


  1. Li Zhu, Zhiguang Huo, Tianzhou Ma, George Tseng. (2018). Bayesian indicator variable selection incoporate multi-layer overlaping group structure in multi-omics application. (Minor revision in The Annals of Applied Statistics. An earlier version won ENAR distinguished student paper award 2018 ).

  2. Li Zhu*, Ying Ding*, Cho-Yi Chen*, Lin Wang, Zhiguang Huo, SungHwan Kim, Christos Sotiriou, Steffi Oesterreich, and George C. Tseng. (2016). MetaDCN: meta-analysis framework for differential coexpression network detection with an application in breast cancer, Bioinformatics. (presented in 2016 Great Lakes Bioinformatics and the Canadian Computational Biology Conference (GLBIO/CCBC)). (* co-first author)

  3. Zhiguang Huo, Li Zhu, Tianzhou Ma, Song Han, Daiqing Liao, Zhao Jinying and George Tseng. (2018). Two-way horizontal and vertical omics integration for disease subtype discovery. (Under revision in Statistics in Biosciences).

  4. Zhou Fang, Tianzhou Ma, Tang Gong, Li Zhu, George C. Tseng. (2018). Bayesian integrative model for multi-omics data with missingness. Bioinformatics.

  5. Tianzhou Ma, Zhiguang Huo, Anche Kuo, Li Zhu, Zhou Fang, Xiangrui Zeng, Chien-Wei Lin, Silvia Liu, Lin Wang, Tanbin Rahman, Lun-Ching Chang, Sunghwan Kim, Jia Li, Yongseok Park, Chi Song, Steffi Oesterreich, Etienne Sibille and George C. Tseng. (2018). MetaOmics: Comprehensive Analysis Pipeline and Browser-based Software Suite for Transcriptomic Meta-Analysis. Bioinformatics.

  6. Brian Neelon, Li Zhu, Sara E. Neelon. (2015). Bayesian two-part spatial models for semicontinuous data with application to emergency department expenditures. Biostatistics 16(3), 465-79.

  7. Li Zhu*, Jessica L. Narloch*, Sayali Onkar*, Marion Joy, Catherine Luedke, Allison Hall, Rim Kim, Katherine Pogue-Geile, Sarah Sammons, Naema Nayyar, Ugonma Chukwueke, Priscilla K. Brastianos, Carey K. Anders, Adam C. Soloff, Dario AA Vignali, George C. Tseng, Leisha A. Emens, Peter C. Lucas, Kimberly L. Blackwell, Steffi Oesterreich, Adrian V. Lee. Metastatic breast cancers have reduced immune cell recruitment but harbor increased macrophages relative to their matched primary tumors (submitted to Cancer Immunol Res, preprint bioRxiv 10.1101/525071).(* authors contributed equally).

  8. Min Han, Arsalan Salamat, Li Zhu, Huina Zhang, Beth Z Clark, David J Dabbs, Adam Brufsky, Rachel Jankowitz, Shannon Puhalla, Ronald R Johnson, Atilla Soran, Jennifer Steiman, Priscilla McAuliffe, Emilia Diego, Rohit Bhargava. (2018). Metaplastic breast carcinoma: A clinical-pathologic study of 97 cases with subset analysis of response to neoadjuvant chemotherapy. Modern Pathology.

  9. Nilgun Tasdemir, Emily Bossart, Zheqi Li, Zhu Li, Kevin Levine, Britta Jacobsen, George C. Tseng, Nancy E. Davidson, Steffi Oesterreich. (2018). Comprehensive 2D and 3D phenotypic characterization of human invasive lobular carcinoma cell lines. Cancer Research.

  10. Damir Vareslija, Nolan Priedigkeit, ..., Li Zhu, George C. Tseng, ..., Steffi Oesterreich, Adrian V. Lee, and Leonie S. Young. (2018) Transcriptome characterization of matched primary breast and brain metastatic tumors to detect novel actionable targets. JNCI.

  11. Alessandra Landmann, Daniel J. Farrugia, Li Zhu, Emilia J. Diego, Ronald R. Johnson, Atilla Soran, David J. Dabbs, Beth Z. Clark, Shannon L. Puhalla, Rachel C. Jankowitz, Adam M. Brufsky, Gretchen M. Ahrendt, Priscilla F. McAuliffe, and Rohit Bhargava. (2018). Low estrogen receptor (ER) positive breast cancer and neoadjuvant systemic chemotherapy: Is response similar to typical ER positive or ER negative disease? American journal of clinical pathology, 150(1), 34-42.

  12. Tian Du, Li Zhu, Kevin M. Levine, Nilgun Tasdemir, Adrian V Lee, Bennett Van Houten, George C. Tseng, Steffi Oesterreich. (2017). Invasive lobular and ductal breast carcinoma differ in immune response, protein translation efficiency and metabolism. Scientific Reports. 8(1):7205.

  13. Daniel J. Farrugia, Alessandra Landmann, Li Zhu, Emilia J. Diego, Ronald R. Johnson, Marguerite Bonaventura, Atilla Soran, David J. Dabbs, Beth Clark, Shannon L. Puhalla, Rachel Jankowitz, Adam M. Brufsky, Barry Lembersky, Gretchen M. Ahrendt, Priscilla F. McAuliffe, and Rohit Bhargava. (2017). Magee Equation 3 (ME3) predicts pathologic response to neoadjuvant systemic therapy in estrogen receptor positive, HER2 negative/equivocal breast tumors. Modern Pathology, 30, 1078-1085.

Manuscripts in preparation


  1. Li Zhu, George Tseng. Bayesian clustering with multi-layer overlapping group structure.

  2. Li Zhu, Anshun Tsai, Wei Chen, George Tseng. Zero-inflated negative binomial model for single cell RNASeq DE analysis.

  3. Tianzhou Ma, Tanbin Rahman, Li Zhu, Xiangrui Zeng, Jingyi J. Li and George C. Tseng. Poorly mimic or greatly mimic? A model-based evaluation with functional characterization for comparison of differential transcriptomic systems across model organisms or across species.

Conference presentations


  1. "Bayesian indicator variable selection model with multi-layer overlapping groups" in ENAR 2018 (Atlanta, USA).

  2. “MetaDCN: meta-analysis framework for differential co-expression network detection with an application in breast cancer” in Great Lakes Bioinformatics and the Canadian Computational Biology Conference (GLBIO/CCBC) 2016 (Toronto, Canada).

  3. “Using biomarkers to enhance 60-day in hospital mortality prediction for early sepsis patients” in 45th Critical Care Congress 2016 (Orlando, USA).

Experience


Teaching


Award


Certificate