Jim's Homepage

I'm a freshman at the University of Pittsburgh at Bradford, and im currently enrolled as a premed student. There's a lot of things I like about school: freedom, independence, responsibility, and living in a dorm to mention a few, but my favorite thing is my classes. They're hard and require a lot of work, but its fun to learn all these new things I haven't studied before.

Here is some more info about me:

  • Favorite food: I love Mexican food, they really know how to flavor things.
  • Favorite Artist: My favorite artist at the moment is Judge Jules, a Progressive Trance DJ from England. I'm going to see him this summer at a club called Gatecrasher in Sheffield, England.
  • What I'm most proud of: I would have to say my Irish heritage and my knowledge of music.
  • 10 Years from now: 10 years from now I would like to be living in New York City or San Francisco, hopefully unmarried with a good bit of money to have fun with.
  • Favorite Quote: "Nothing ever came of a life that was a simple one." - Dave King
  • What needs changing: The only think I can think of that needs changing is the general assumption that something needs changing. We're fine the way we are. If we weren't, we wouldn't be here.


A Neuroscience Topic That Interests Me...

Drug Addiction: A Scientific Perspective


We all know that drug addiction is a terrible thing to deal with, especially when it's a true, full on addiction. We can start off with a base definition of the word drug. A drug can be defined as any substance that affects the mind or body (American Heritage, p264). In the sense we are talking about, a drug is any substance that an individual might use to get high.


The two drugs that have the highest rate of addiction are nicotine, which is found in mostly all tobacco products and alcohol. Nicotine is extremely addictive and once a person is addicted, it is one of the hardest things to shake. The body becomes used to rush felt when dopamine is released, and there becomes an urge for more and more of it. This is how addiction works. The body becomes tolerant to a certain drug and more is needed every time to experience the high. The body then becomes used to this state and sees it as normal.


In the brain there are "reward pathways", or mesolimbic-dopamine pathways, which cause pleasure. When drugs are used, a neurotransmitter called dopamine is released to these pathways and the user feels pleasure. When this feeling subsides, the user feels the need to continue the pleasurable feelings and goes for more, usually a larger dose of the substance (NIDA, Nicotine Research).


An addiction can be described as a compulsive physiological dependence on a controlled substance. This can lead to an individual being controlled by his need for the drug. Not having the drug can have detritus side affects as well. A person can experience mood swings, depression, tremors, vomiting, hallucinations, chills, and insomnia. This is caused by the body trying to compensate for the lack of the substance. These physical withdrawal symptoms are called Florid Withdrawal Symptoms.


Addiction is a result of prolonged drug use, but it is no longer in the voluntary drug use stages. Addiction is an uncontrollable craving for the drug, caused by changes the drug has made on the brain. The drug could change how a person reacts to certain situations, emotions, or the drug could control the way the person feels in general.


Many times, with use of the more serious drugs, such as heroin and crack cocaine, the user stops using the drug to get the high, because the high is no longer there, due to loss of dopamine. Instead they use the drug to keep themselves from getting sick. They try for the dopamine release, but there's nothing left to release.


On another note, the answer to the question of drug use killing brain cells is yes. Using inhalants actually destroys brain tissue, and using methamphetamines actually destroys dopamine and seratonin neurons (USIA Electronic Journal, 6/97), some of these destroyed parts can never fully grow back or regenerate.


Addiction causes many problems, changes in the brain, destruction of tissues and neurons, and many other social problems that could fill page upon page with their effects. The fact that drugs can irreparably alter your brain and how it functions should in itself keep people from doing them.

Sources

"Nicotine Addiction Research" NIDA, National Institution on Drug Abuse: Alan I Leshner Ph.D. http://165.112.78.61/ResearchReports/Nicotine/Nicotine.html

American Heritage Dictonary, 4th edition. Joseph P. Pickett, ed. (pg 264).

USIA Electronic Journal, Vol.2, No.3, June 1997.