The LIU Group


  1. 39.Matthew L. Hillwig and Xinyu LiuA new family of iron-dependent halogenases acts on freestanding substrates” Nat. Chem. Biol. 2014, 10, doi: 10.1038/nchembio.1625

  1. 38.Jiantao Zhang, Zhongyu Cai, Daniel H. Kwak, Xinyu Liu and Sanford A. Asher “Two-Dimensional Photonic Crystal Sensors for Visual Detection of Lectin Concanavalin A” Anal Chem 2014, DOI: 10.1021/ac5015854

37.Peter A Keyel, Matthew Romero , Wenbo Wu, Daniel H Kwak, Qin Zhu, Xinyu Liu and Russell D Salter “Methylthioadenosine Impairs Macrophage Activation Through Adenosine Receptor Stimulation” PLoS ONE 2014, 9, e104210

  1. 36.Amit Vikram, Vanessa Ante, Xiaowen R. Bina, Qin Zhu, Xinyu Liu, and James E. Bina, “Cyclo(Valine-Valine) inhibits Vibrio cholerae virulence gene expression” Microbiology. 2014, 160, 1054-1062.

  1. 35.Matthew L. Hillwig, Heather A. Fuhrman, Kuljira Ittiamornkul, Tyler J. Sevco, Daniel H. Kwak and Xinyu LiuIdentification and Characterization of A Welwitindolinone Alkaloid Biosynthetic Gene Cluster in Stigonematalean Cyanobacterium Hapalosiphon welwitschii” ChemBioChem, 2014, DOI: 10.1002/cbic.201300794. (Issue 2014/05 inside cover story)

  1. 34.Yao Li and Xinyu LiuAcid-tunable Ester Protective Groups in Oligosaccharide Synthesis” Chem. Commun. 2014, 50, 3155-3158.

  1. 33.Matthew Hillwig, Qin Zhu and Xinyu Liu, “Biosynthesis of Ambiguine Indole Alkaloids in Cyanobacterium Fischerella ambigua” ACS Chem Biol. 2014, 9, 372-377.

  1. 32.Yanyan Liu, Hong Wei Chu, Xinyu Liu, Ling Wang, Sally Wenzel and Y. Peter Di, “Increased susceptibility to pulmonary Pseudomonas infection in Splunc1 knockout mice” J. Immunol. 2013, 191, 4259-4268.

  1. 31.Jiantao Zhang, Xing Chao, Xinyu Liu and Sanford A Asher, "Two-Dimensional Array Debye Ring Diffraction Protein Recognition Sensing" Chem. Commun. 2013,49, 6337-6339.

  1. 30.Robert M Q Shanks, Roni M Lahr, Nicholas A Stella, Kristin E Arena, Kimberly M Brothers, Daniel H Kwak, Xinyu Liu, and Eric J Kalivoda, “A Serratia marcescens PigP Homolog Controls Prodigiosin Biosynthesis” PLoS ONE, 2013, 8, e57634.

  1. 29.Yu-Hsuan Tsai, Xinyu Liu and Peter H. Seeberger, “Chemical Biology of Glycosylphosphatidylinositol Anchors” Angew. Chem. In. Ed. 2012, 51, 11438-11456. (Invited Review)


  1. 28.Robert M. Q. Shanks, Nicholas A. Stella, Roni Lahr, Shaoru Wang, Tara I. Veverka,   Regis P. Kowalski and Xinyu Liu,Serratamolide is a Hemolytic Factor Produced by Serratia marcescens” PLoS One, 2012, 7, e36398.     

  1. 27.Yao Li, Bimalendu Roy and Xinyu Liu,New insight on 2-naphthylmethyl (NAP) ether as protecting group in carbohydrate synthesis: divergent approach towards high-mannose-type oligosaccharide library” Chem. Commun. 2011, 47, 8952–8954.

Prior to University of Pittsburgh:

26.Marie-Lyn Hecht, Yu-Hsuan Tsai, Xinyu Liu, Christian Wolfrum and Peter H. Seeberger, “Insulin-mimetic Activity of Synthetic Inositol Phosphoglycans” ACS Chem. Biol. 2010, 5, 1075–1086.

25.Brian D. Ames, Xinyu Liu and Christopher T. Walsh, “Enzymatic Processing of Fumiquinazoline F: A Tandem Oxidative-Acylation Strategy for the Generation of Multicyclic Scaffolds in Fungal Indole Alkaloid Biosynthesis” Biochemistry 2010, 49, 8564–8576.

24.Marco Tamborrini, Xinyu Liu, Joseph Paschal Mugasa, Yong-Uk Kwon, Faustin Kamena, Peter H. Seeberger and Gerd Pluschke, “Synthetic glycosylphosphatidylinositol microarray reveals differential antibody levels and fine specificities in children with mild and severe malaria.” Bioorg. Med. Chem. 2010, 18, 3747-52.

23.Raghavendra Kikkeri, Xinyu Liu, Alexander Adibekian, Yu-Hsuan Tsai and Peter H. Seeberger, “Facile Synthesis of Size Dependent Ru(II)-Carbohydrate Dendrimers via Click Chemistry” Chem. Comm. 2010, 46, 2197-2199. “Featured as hot article of February 2010 by Chem. Comm.”

22.Xinyu Liu and Christopher T. Walsh, “Characterization of cyclo-Acetoacetyl-L-Tryptophan Dimethylallyltransferase in Cyclopiazonic Acid Biosynthesis: Substrate Promiscuity and Site Directed Mutagenesis Studies” Biochemistry 2009, 48, 11032-11044.

21.Xinyu Liu and Christopher T. Walsh, “Cyclopiazonic Acid Biosynthesis in Aspergillus sp.: Characterization of a reductase-like R* domain in cyclopiazonate synthetase that forms and releases cyclo-acetoacetyl-L-tryptophan”, Biochemistry 2009, 48, 8746-8757.

20.Xinyu Liu, Daniel Varon Silva, Faustin Kamena and Peter H. Seeberger, “GPI-Base Malarial Vaccine: Past, Present and Future” In: Anant K. Menon, Taroh Kinoshita, Peter Orlean, Fuyu Tamanoi (Eds) Glycosylphosphatidylinositol (GPI) Anchoring of Proteins, Academic Press, 2009, 229-245.

19.Faustin Kamena, Xinyu Liu and Peter H. Seeberger, “Carbohydrate-Based Antiparasitic Vaccines” In: Zhongwu Guo, Geert-Jan Boons (Eds) Carbohydrate-Based Vaccines, Wiley-VCH, Weinheim, 2009, 193-212.

18.Siwarutt Boonyaranattakalin, Xinyu Liu, Mario Michieletti, Bernd Lepenies and Peter H. Seeberger, “Chemical Synthesis of All Phosphatidylinositol Mannoside (PIM) Glycans from Mycobacterium tuberculosis”, J. Am. Chem. Soc. 2008, 130, 16791-16799.

17.Jakob P. Cramer, Bernd Lepenies, Faustin Kamena, Christoph Holschere, Marina A. Freudenberg, Gerd D. Burchard, Hermann Wagnerg, Carsten J. Kirschning, Xinyu Liu, Peter H. Seeberger and Thomas, “MyD88/IL-18-Dependent Pathways Rather than TLRs Control Early Parasitaemia in Non-lethal Plasmodium yoelii Infection”, Microb. Infect. 2008, 10, 1259-1265.

16.Christian F. W. Becker, Xinyu Liu, Diana Olschewski, Riccardo Castelli, Ralf Seidel and Peter H. Seeberger, ”Semisynthesis of a Glycosylphosphatidylinositol-Anchored Prion Protein”, Angew. Chem. Int. Ed. 2008, 47, 8215–8219. This paper was extensively highlighted by the global media, including New Scientists as “First synthetic prion could settle vCJD controversy”, Science Daily News as “Tracking Down The Cause Of Mad Cow Disease: First Synthetic Prion Protein With An Anchor”, Medical News Today as “Hot On The Heels Of The Mad Cow Pathogen - First Synthetic Anchored Prion”, Nature as “Prion Progress” and Chemical & Engineering News as “Synthetic Anchored Prion Protein Created”.

15.Masaki Shimizu, Takuya Fujimoto, Xinyu Liu, Youhei Takeda and Tamejiro Hiyama, “Stereoselective Preparation and Cope Rearrangement of 2-CF3-cis-2,3-bis(alkenyl)oxiranes: A Facile Approach to 2-CF3-substituted Oxacycles“, Heterocycles 2008, 76, 329–351.

14.Xinyu Liu, Pascal D. Fortin and Christopher T. Walsh, “Andrimid Producers Encode an Acetyl-CoA Carboxyltransferase Subunit Resistant to the Action of the Antibiotic”, Proc. Natl. Acad. Sci. USA, 2008, 105, 13321-13326.

13.Norbert W. Brattig, Katharina Kowalsky, Xinyu Liu , Gerd D. Burchard, Faustin Kamena and Peter H. Seeberger. “Plasmodium falciparum Glycosylphosphatidylinositol Toxin Interacts with the Membrane of Nonparasitized Red Blood Cells: a Putative Mechanism Contributing to Malaria Anemia”, Microb. Infect. 2008, 10, 885-891.

12.Xinyu Liu, Reiko Wada, Siwarutt Boonyaranattakalin, Bastien Castagner and Peter H. Seeberger, “Automated Synthesis of Lipomannan Backbone α(1-6) Oligomannoside via Glycosyl Phosphate: Glycosyl Tricyclic Orthoester Revisited”, Chem. Comm. 2008, 3510–3512.

11.Faustin Kamena, Marco Tamborrini, Xinyu Liu, Yong-Uk Kwon, Gerd Pluschke, Fiona Thompson and Peter H. Seeberger, “Synthetic GPI-Array to Study Anti-toxic Malaria Repsonse”, Nature Chem. Biol. 2008, 4, 238-240. This paper was featured as the cover of Nature Chemical Biology, issue 4, 2008 and complimentarily commented by Professor Michael A J Ferguson in the same issue. Further highlights include those in Chemical & Engineering News (ACS) as “Sugar Arrays Gauge Malaria Response”, 2008, March 17, pp42, and other global media, such as Science Daily News, Future Drugs, Frankfurt General Newspaper and The World Newspaper.

10.Xinyu Liu, Sibylle Siegrist, Mario Amacker, Rinaldo Zurbriggen, Gerd Pluschke and Peter H. Seeberger, “Enhancement of the Immunogenicity of Synthetic Carbohydrates by Conjugation to Virosomes: A Leishmaniasis Vaccine Candidate”, ACS Chem. Biol. 2006, 1, 161–164. This paper was extensively highlighted by global media, including BBC News as “Hope for Tropical Disease Vaccine”, Chemical & Engineering News (ACS) as “Vaccine Candidate for Leishmaniasis” and Hindustan Times as “Vaccine Developed to Fight Black Fever”.

9.Alessandra Ravida, Xinyu Liu, Linda Kovacs and Peter H. Seeberger, “Synthesis of Glycosyl Phosphates from 1,2-Orthoesters and Application to in situ Glycosylation Reactions”, Org. Lett. 2006, 8, 1815–1818.

8.Xinyu Liu, Bridget L. Stocker and Peter H. Seeberger, “Total Synthesis of Phosphatidylinositol Mannosides of Mycobacterium tuberculosis”, J. Am. Chem. Soc. 2006, 128, 3638–3648.

7.Yong-Uk Kwon, Xinyu Liu and Peter H. Seeberger, “Total Syntheses of Fully Lipidated Glycosylphosphatidylinositol Anchors of Toxoplasma gondii”, Chem. Comm. 2005, 2280–2282.

6.Xinyu Liu, Yong-Uk Kwon and Peter H. Seeberger, “Convergent Synthesis of a Fully Lipidated Glycosylphosphatidylinositol Anchor of Plasmodium falciparum”, J. Am. Chem. Soc. 2005, 127, 5005–5006. This work was highlighted as the Year-2006 cover picture of Carbohydrate Research.

5.Xinyu Liu and Peter H. Seeberger, “A Suzuki-Miyaura Coupling Mediated Deprotection as Key to the Synthesis of A Fully Lipidated Malarial GPI Disaccharide“, Chem. Comm. 2004, 1708–1709. This paper was highlighted by Science Magazine (AAAS) in Editor’s Choice as “Synthetic GPIs”, Science, 2004, 305, 1079; and Chemistry World (RCS) as “A Malaria Miracle?”, 2004 August, pp25.

4.Masaki Shimizu, Takuya Fujimoto, Xinyu Liu and Tamejiro Hiyama, “A Facile Approach to 2-CF3-substituted Seven-membered Oxacycles via Stereoselective Preparation and Cope Rearrangement of 2-CF3-cis-2,3-bis(alkenyl)oxiranes“, Chem. Lett. 2004, 33, 438–439.

3.Xinyu Liu, Masaki Shimizu and Tamejiro Hiyama, “A Facile Stereocontrolled Approach to CF3-substituted Triarylethenes: Synthesis of Panomifene“, Angew. Chem. Int. Ed. 2004, 43, 879–882.

2.Xinyu Liu,Bis(pinacolato)diboron“, Synlett. 2003, 15, 2442–2443.

1.Masaki Shimizu, Takuya Fujimoto, Xinyu Liu, Hiroshi Minezaki, Takeshi Hata and Tamejiro Hiyama, “Stereoselective Generation of cis-2-Lithio-3-CF3-oxirane via CF3-Substituted β-Oxido Carbenoids and by Stereospecific Reaction: Highly Stereoselective Synthesis of CF3-Substituted Tri- and Tetrasubstituted Oxiranes and Tetrasubstituted Alkenes”, Tetrahedron 2003, 59, 9811–9823.