Vladimir Tyurin

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Department of Environmental and Occupational Health

Vladimir Tyurin - Publications - past 5 years

Tyurin, VA, Tyurina, YY, Osipov, AN, Belikova, NA, Basova, LV, Kapralov, AA, Bayer, H, Kagan VE. Interactions of cardiolipin and lyso-cardiolipins with cytochrome c and tBid: conflict or assistance in apoptosis. Cell Death. Differ., 14(4):872-5, 2007. PMID: 17170752

Tyurina, YY, Basova, LV, Konduru, NV, Tyurin, VA, Potapovich, AI, Cai, P, Bayer, H, Stoyanovsky, D, Pitt, BR, Shvedova, AA, Fadeel, B, Kagan, VE. Nitrosative stress inhibits the aminophospholipid translocase resulting in phosphatidylserine externalization and macrophage engulfment: Implications for the resolution of inflammation. J. Biol. Chem., 282(11): 8498-509, 2007. PMID: 17229723

Bayir H, Tyurin VA, Tyurina, YY, Viner, R, Ritov, V, Amoscato, AA, Zhao, Q, Zhang, XJ, Janesko-Feldman, KL, Alexander H, Basova LL, Clark RSB, Kochanek PM, Kagan VE. Selective early cardiolipin peroxidation after traumatic brain injury: An oxidative lipidomics analysis. Ann. Neurol., 62, 154-169, 2007. PMID: 17685468

Tyurin, VA, Tyurina, YY, Ritov, VB, Lysytsya, A, Amoscato, AA, Kochanek, PM, Hamilton, R, DeKosky, ST, Greenberger, JS, Bayir, H, Kagan, VE. Oxidative lipidomics of apoptosis: Quantitative assessment of phospholipid hydroperoxides in cells and tissues. Meth. Mol. Biol., 2007, in press.

Kapralov, AA, Kurnikov, IV, Vlasova, II, Belikova, NA, Tyurin, VA, Basova, LV, Zhao, Q, Tyurina, YY, Jiang, J, Bayir, H, Vladimirov, YA, Kagan, VE. Hierarchy of structural transitions induced in cytochrome c by anionic phospholipids determines its peroxidase activation and selective peroxidation during apoptosis in cells. Biochemistry, 2007, PMID: 18004876.

Tyurin VA, Tyurina YY, Kochanek PM, Hamilton R, Dekosky ST, Greenberger JS, Bayir H, Kagan VE. Chapter nineteen oxidative lipidomics of programmed cell death. Methods Enzymol. 2008;442:375-93. PMID: 18662580

Du L, Hickey RW, Bayir H, Watkins SC, Tyurin VA, Guo F, Kochanek PM, Jenkins LW, Ren J, Gibson G, Chu CT, Kagan VE, Clark RS. Starving Neurons Show Sex Difference in Autophagy. J Biol Chem. 2008 Nov 25. PMID: 19036730

Borisenko, G. G. Kapralov, A. A. Tyurin, V. A. Maeda, A. Stoyanovsky, D. A. and Kagan, V. E. Molecular Design of New Inhibitors of Peroxidase Activity of Cytochrome c/Cardiolipin Complexes: Fluorescent Oxadiazole-Derivatized Cardiolipin. Biochemistry, November 2008.

Tyurin VA, Tyurina YY, Feng W, Mnuskin A, Jiang J, Tang M, Zhang X, Zhao Q, Kochanek PM, Clark RS, Bayır H, Kagan VE. Mass-Spectrometric Characterization of Phospholipids and their Primary Peroxidation Products in Rat Cortical Neurons During Staurosporine-Induced Apoptosis. J Neurochem. 2008 Nov 6. PMID: 19014376

Maki RA, Tyurin VA, Lyon RC, Hamilton RL, Dekosky ST, Kagan VE, Reynolds WF. Aberrant expression of myeloperoxidase in astrocytes promotes phospholipid oxidation and memory deficits in a mouse model of Alzheimer's disease. J Biol Chem. 2008 Dec 5. PMID: 19059911

Kagan VE, Bayır HA, Belikova NA, Kapralov O, Tyurina YY, Tyurin VA, Jiang J, Stoyanovsky DA, Wipf P, Kochanek PM, Greenberger JS, Pitt B, Shvedova AA,Borisenko G. Cytochrome c/cardiolipin relations in mitochondria: A kiss of death. Free Radic Biol Med. 2009 Mar 11. PMID: 19285551

Bayir H., Kapralov A.A., Jiang J., Huang Z., Tyurina Y.Y., Tyurin V.A., Zhao Q., Belikova N.A., Vlasova I.I., Maeda A., Zhu J., Na H.M., Mastroberardino P.G., Sparvero L.J., Amoscato A.A., Chu C.T., Greenamyre J.T., Kagan V.E. Peroxidase mechanism of lipid dependent cross-linking of synuclein with cytochrome c: protection against apoptosis versus delayed oxidative stress in Parkinson's disease. J. Biol. Chem., 2009, 284(23): 15951-15969.

Tyurin VA, Tyurina YY, Jung MY, Tungekar MA, Wasserloos KJ, Bayir H, Greenberger JS, Kochanek PM, Shvedova AA, Pitt B, Kagan VE. Mass-spectrometric analysis of hydroperoxy- and hydroxy-derivatives of cardiolipin and phosphatidylserine in cells and tissues induced by pro-apoptotic and pro-inflammatory stimuli. J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Mar 13. PMID: 19328050

Belikova NA, Tyurina YY, Borisenko G, Tyurin VA, Samhan Arias AK, Yanamala N, Furtmuller PG, Klein-Seetharaman, Obinger C, Kagan VE. Heterolytic reduction of fatty hydroperoxides by cytochrome c-cardiolipin complexes: antioxidant function in mitochondria. Am Chem Soc. 2009 Aug 19;131(32):11288-9. PMID: 19627079

Tyurina YY, Tyurin VA, Kapralova VI, Amoscato AA, Epperly MW, Greenberger JS, Kagan VE. Mass-spectrometric characterization of phospholipids and their hydroperoxide derivatives in vivo: effects of total body irradiation. Methods Mol Biol. 2009;580:153-83. PMID: 19784599

Tyurin VA, Tyurina YY, Ritov VB, Lysytsya A, Amoscato AA, Kochanek PM, Hamilton R, Dekosky ST, Greenberger JS, Bayir H, Kagan VE. Oxidative lipidomics of apoptosis: quantitative assessment of phospholipid hydroperoxides in cells and tissues. Methods Mol Biol. 2010;610:353-74. PubMed PMID: 20013189

Li W., Wu S., Ahmad M., Jiang J., Liu H., Nagayama T., Rose M.E., Tyurin V.A., Tyurina Y.Y., Borisenko G.G., Belikova N., Chen J., Kagan V.E., Graham S.H. The cyclooxygenase site, but not the peroxidase site of cyclooxygenase-2 is required for neurotoxicity in hypoxic and ischemic injury. J. Neurochem., 2010, 113(4), 965-977. PMID: 20236388

Tyurina Y.Y., Tyurin V.A., Kaynar A.M., Kapralova V.I., Wasserloos K.J., Li J., Mosher M., Wright L., Wipf P., Watkins S.K., Pitt B.R., Kagan V.E. Oxidative lipidomics of hyperoxic acute lung injury: Mass spectrometric characterization of cardiolipin and phosphatidylserine peroxidation. Am. J. Physiol. Lung Cell Mol. Physiol. 2010, Apr 23. PMID: 20418384

Herber D.L., Cao W., Nefedova Y., Novitskiy S.V., Nagaraj S., Tyurin V.A., Corzo A., Cho H.I., Celis E., Lennox B., Knight S.C., Padhya T., McCaffrey T.V., McCaffrey J.C., Antonia S., Fishman M., Ferris R.L., Kagan V.E., Gabrilovich D.I. Lipid accumulation and dendritic cell dysfunction in cancer. Nature. Med., 2010, 16(8), 880-6. PMID:20622859

Tyurina YY, Tyurin VA, Kapralova VI, Wasserloos K, Mosher M, Epperly MW, Greenberger JS, Pitt BR, Kagan VE. Oxidative lipidomics of ϒ-radiation-induced lung injury: mass spectrometric characterization of cardiolipin and phosphatidylserine peroxidation. Radiat Res. 2011 May;175(5):610-21. Epub 2011 Feb 21. PMID:21338246

Tyurin VA, Cao W, Tyurina YY, Gabrilovich DI, Kagan VE. Mass-spectrometric characterization of peroxidized and hydrolyzed lipids in plasma and dendritic cells of tumor-bearing animals. Biochem Biophys Res Commun. 2011 Sep 16;413(1):149-53. Epub 2011 Aug 22. PubMed PMID: 21872574

Atkinson J, Kapralov AA, Yanamala N, Tyurina YY, Amoscato AA, Pearce L, Peterson J, Huang Z, Jiang J, Samhan-Arias AK, Maeda A, Feng W, Wasserloos K, Belikova NA, Tyurin VA, Wang H, Fletcher J, Wang Y, Vlasova II, Klein-Seetharaman J, Stoyanovsky DA, Bayîr H, Pitt BR, Epperly MW, Greenberger JS, Kagan VE. A mitochondria-targeted inhibitor of cytochrome c peroxidase mitigates radiation-induced death. Nat Commun. 2011 Oct 11;2:497. doi: 10.1038/ncomms1499. PubMed PMID: 21988913

Tyurina YY, Tungekar MA, Jung MY, Tyurin VA, Greenberger JS, Stoyanovsky DA, Kagan VE. Mitochondria targeting of non-peroxidizable triphenylphosphonium conjugated oleic acid protects mouse embryonic cells against apoptosis: Role of cardiolipin remodeling. FEBS Lett. 2011 Dec 28. PubMed PMID: 22210054

Stoyanovsky DA, Huang Z, Jiang J, Belikova NA, Tyurin V, Epperly MW, Greenberger JS, Bayir H, Kagan VE. A manganese-porphyrin complex decomposes H₂O₂, inhibits apoptosis, and acts as a radiation mitigator in vivo. ACS Med Chem Lett. 2011 Nov 10;2(11):814-817. PubMed PMID: 22247787

Samhan-Arias AK, Ji J, Demidova OM, Sparvero LJ, Feng W, Tyurin V, Tyurina YY, Epperly MW, Shvedova AA, Greenberger JS, Bayir H, Kagan VE, Amoscato AA. Oxidized phospholipids as biomarkers of tissue and cell damage with a focus on cardiolipin. Biochim Biophys Acta. 2012 Mar 23. PMID: 22464971

Books and Book Chapters

Tyurin V.A., Tyurina Y.Y., Ritov V.B., Lysytsya A., Amoscato A.A., Kochanek P.M., Hamilton R., DeKosky S.T., Greenberger J.S., Bayer H., Kagan V.E. Oxidative lipidomics of apoptosis: Quantitative assessment of phospholipid hydroperoxides in cells and tissues. Methods in Molecular Biology, 2010, 610, 353-374.

Tyurina YY, Tyurin VA, Kapralova VI, Amoscato AA, Epperly MW, Greenberger JS, Kagan VE. Mass-Spectrometric Characterization of Phospholipids and Their Hydroperoxide-Derivatives in Vivo: Effects of Total Body Irradiation. Methods in Molecular Biology, 580, Chapter 9, 2009.

Tyurin VA, Tyurina YY, Kochanek PM, Hamilton R, DeKosky ST, Greenberger JS, Bayir H, Kagan VE. Oxidative lipidomics of programmed cell death. Methods Enzymol. 442:375-393, 2008.

Invited Articles

Tyurin V.A., Tyurina Y.Y., Jung M.Y., Tungekar M.A., Wasserloos K.J., Bayır H., Greenberger J.S., Kochanek P.M., Shvedova A.A., Pitt B., Kagan V.E. Mass-spectrometric analysis of hydroperoxy- and hydroxy-derivatives of cardiolipin and phosphatidylserine in cells and tissues induced by pro-apoptotic and pro-inflammatory stimuli. J Chromatogr. B Analyt. Technol. Biomed. Life Sci., 2009, Mar 13.
Kagan V.E., Bayır H.A., Belikova N.A., Kapralov O., Tyurina Y.Y., Tyurin V.A., Jiang J., Stoyanovsky D.A., Wipf P., Kochanek P.M., Greenberger J.S., Pitt B., Shvedova A.A., Borisenko G. Cytochrome c/cardiolipin relations in mitochondria: a kiss of death. Free Radic. Biol. Med., 2009 Mar 12.

Review Articles

Kagan V.E., Bayır H.A., Belikova N.A., Kapralov O., Tyurina Y.Y., Tyurin V.A., Jiang J., Stoyanovsky D.A., Wipf P., Kochanek P.M., Greenberger J.S., Pitt B., Shvedova A.A., Borisenko G. Cytochrome c/cardiolipin relations in mitochondria: a kiss of death. Free Radic. Biol. Med., 2009 Mar 12.

Published Abstracts

Tyurin V.A., Winnica D., Fazzi F., Feng W., Tyurina Y.Y., Stewart N.A., Kisin E.R., Murray A.R., Shvedova A.A., Pitt B.R., Kagan V.E., Ortiz L.A. Phospholiopid oxidative metabolism during macrophage response to environmental agents. 49^th Annual Meeting for Society of Toxicology; The Toxicologist: Suppl. V.114, No 1, Abstract No. 599, p.128, March 8-11, 2010, Salt Lake City, UT.

Tyurina Y.Y., Tyurin V.A., Kapralova V.I., Wasserloos K., Mosher M., Epperly M., Greenberger J., Pitt B., Kagan V.. Oxidative lipidomics of gamma-radiation induced lung injury. 49^th Annual Meeting for Society of Toxicology; The Toxicologist: Suppl. V.114, No 1, Abstract No. 597, p.128, March 8-11, 2010, Salt Lake City, UT.

Kagan V.E., Tyurin V.A., Kapralova V., Kaynar M., Wasserloos K., Mosher M., Wipf, P., Pitt B., Tyurina Y.Y. Oxidative lipidomics of hyperoxia-induced acute lung injury. 49^th Annual Meeting for Society of Toxicology; The Toxicologist: Suppl. V.114, No 1, Abstract No. 598, p.128, March 8-11, 2010, Salt Lake City, UT.

Tyurin VA, Jung MY, Tyurina YY, Prieto T, Zhao Q, Kapralov AA, Belikova NA, Nantes I, Kagan VE Cardiolipin oxidation, hydrolysis and accumulation of monolysocardiolipins and oxidized free fatty acids during apoptosis: Role cytochrome c. 302#448, 48^th Annual Meeting, Society of Toxicology, Baltimore, MD, March, 2009.

Feng W, Tyurin VA, Go KI, Tyurina YY, Stewart NA, Fazzi F, Kisin ER, Murray AR, Shvedova AA, Pitt BR, Ortiz LA, Kagan VE Oxidative lipidomics of macrophage activation and apoptosis induced by phagocytosis of particles and pathogens., 936#434. 48^th Annual Meeting, Society of Toxicology, Baltimore, MD, March, 2009.

Tyurina YY, Tyurin VA, Kapralova VI, Tugekar A, Kaynar M, Wasserloos K, Mosher M, Epperly M, Greenberger JS, Pitt BR, Kagan VE. Oxidative lipidomics of acute lung injury induced by hyproxia and gamma-irradiation. 949#447. 48^th Annual Meeting, Society of Toxicology, Baltimore, MD, March, 2009.

Tyurin V.A., Zhao Q., Mnuskin A., Hamilton R.L., DeKosky S.T., Reynolds W.F. and Kagan V.E. Phospholipid peroxidation biomarkers of Alzheimer’s disease in the brain: selective oxidation of phosphatidylserine. 47^th Annual Meeting, Sosiety of Toxicology, Seattle, WA, The Toxicologist, # 1961, p. 404, 2008.

BorisenkoG.G., Kapralov A., Tyurin V.A., and Kagan V.E. Modified cardiolipin homologues as inhibitors of pro-apoptotic peroxidase function of cytochrome c. 47^th Annual Meeting, Sosiety of Toxicology, Seattle, WA, The Toxicologist, # 1392, p. 285, 2008.

Tyurin V.A., Bayir H., Tyurina Y.Y., Feng W., Viner R., Amoscato A.A., Zhao Q., Janesko-Feldman K., Alexander H., Kochanek P.M., DeKosky S. T. and Kagan V. E. Mass spectrometric analysis of phospholipid molecular species and their hydroperoxides in apoptotic neurons and injured rat brain. 46^th Annual Meeting, Society of Toxicology, Chalotte, NC, 2007, #187, p. 39.

Vlasova I.I., Kapralov A.A., Jiang J., Basova L.V., Belikova N.A., Tyurin V.A., Tyurina Y.Y., Martin J., Glumac A., Bayir H. and Kagan V.E. Peroxidase complexes of cytochrome c with anionic lipids: Structutal pre-requisites, mechanisms, and cytotoxic effects. 46^th Annual Meeting, Society of Toxicology, Chalotte, NC, 2007, #292, p. 61.

Tyurina Y.Y., Tyurin V.A., Epperly M.W., Greenberger J.S. and Kagan V.E. Oxidized cardiolipin as a new biomarker of gamma-irradiation-induced apoptosis. 46^th Annual Meeting, Society of Toxicology, Chalotte, NC, 2007, #294, p. 61.

Samhan-Arias AK, Ji J, Demidova OM, Sparvero LJ, Feng W, Tyurin V, Tyurina YY, Epperly MW, Shvedova AA, Greenberger JS, Bayir H, Kagan VE, Amoscato AA. Oxidized phospholipids as biomarkers of tissue and cell damage with a focus on cardiolipin. Biochim Biophys Acta. 2012 Mar 23. PMID: 22464971