Writing Group for the PEPI Trial. JAMA, 1996;276:1389–96.

CEE: conjugated equine estrogen; MPA: medroxyprogesterone acetate; MP: micronized progesterone;

cyc: cyclic admin. (days 1–12 of each month); and con: continuous admin. (daily throughout the month)

The PEPI study included 2,763 postmenopausal women.

Age = 45-64 years

3-year study (randomized, double-blind, placebo-controlled)

Drug = CEE only, CEE-MPA cyclic, CEE-MPA continuous, or CEE-MP cyclic

Primary Endpoint = Hip and spine BMD