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Here is some very recent data that was just submitted for publication, which I think is very provocative. These are actually data that Kathy Carlson is first author on (and some of the slides at the beginning of this presentation were hers as well). There’s only real been one longitudinal study of PID ever conducted. That study had, in a sense, a real control group – those women who underwent laparoscopy but in fact turned out not to have the clinical evidence of PID. All of these data about infertility, chronic pelvic pain, and ectopic pregnancy come from this one longitudinal Scandinavian study. In a sense, the PEACH study represents the only other prospective study ever done in the area of PID. It may be a big one but we don’t have an obvious control group, except, that all of these women had endometrial biopsies, which is our surrogate marker for PID because women who have Salpingitis, the inflammation of the tubes and ovaries, very commonly also have endometritis. So if we consider endometritis and/or upper genital tract infection, that is to say if we could literally isolate Gonorrhea or Chlaymidia in the upper genital tract or endometrium, we can call that the group of women who have real PID, who have something that’s like Salpingitis, which is about 60% of our population. But we also have, about 40%, of women who actually don’t have endometritis or upper genital tract infection. So let’s compare those two and see what we end up with in terms of outcomes.Clearly, a priori, our expectation was that women who have endometritis and are followed longitudinally, if we compare them to women who don’t, will have higher rates of infertility, chronic pelvic pain, ectopic pregnancy and so on. What you can see is once again we don’t see a relationship in our data between endometritis and upper genital in any of these outcomes. We massaged these data trying to find a relation but there is just nothing there.
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