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|In explaining the aetiology of this atypical phasic insulin
dependence clinical syndrome, an hypothesis has been developed:
- Poor nutrition and bush teas predispose to persistence of free radicals which can cause
- This damage can result in exposed or induced antigens which can elicit antibodies. This
is further aggravated by frequent infections eg viral
- These antibodies can cross react with insulin,its receptors and transporters as well as
islet cells, inter alia.
- This can lead to insulin resistance on the one hand and insufficiency on the other hand,
with the latter being further aggravated by direct dmage to islet cells such as in
- The state of the equilibrium between the insulin resistance and insufficiency can lead
to types 1 & 2 diabetes respectively, with a transitional phasic insulin deficiency
syndrome between these two ends of the spectrum.
This is called THE UNITARIAN HYPOTHESIS, which suggests that from a single toxic
insult, a cascade of reactions can result in either type of diabetes. Herein the atypical
has served to elucidate the typical.