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The major effects of temeperature and functional activity, contractile and electric work, on the metabolic rate of myocardium have been described. Institution of CPB permits emptying of the heart significantly reducing contractile work and myocardial oxygen consumption, MVO2.

Aortic cross clamp application induces ischemia while achevingcardiac arrest. It results in greater reduction in myocardial oxygen consumption than other preservation strategies.The content of cardioplegia must be designed not only to arest the heartn but also to optimally maintain the integrity of myocardial cells during the ischemic period.