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 Biological Plausibility - Sometimes we know, sometimes we don’t Alternate Explaination Eliminated: Hard to prove a negative Cessation Effect: Risk Drops in absence of exposure to the risk factor Specificity of the Association: Specific Exposure Associated with only 1 disease - throw back to Infectious disease theory - Not generally applicable as Shown by previous discussion of Frame Work of Causation Dose response strong evidence for Causal relationship |