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|It could be
suggested that the constant increase in the incidence of type 1 diabetes could be linked
to the combination of changes in the recommendations of vitamin D supplementation, and
compliance in giving the supplementation to the infants. During the decades that incidence
of type 1 diabetes has been increasing, the dose recommendation has been reduced (in
steps) to a tenth of the original level. At the same time, there is some evidence of
reduced compliance in giving vitamin D supplementation and re-occurrence of severe vitamin
D deficiency i.e. rickets.
How would you study the covariation in the temporal changes of vitamin D intake and incidence of type 1 diabetes?
What makes a reliable evaluation of such associations difficult?