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- CRASH is a large simple placebo controlled trial, among adults with head injury and impaired consciousness, of the effects of a 48-hour infusion of corticosteroids on death and neurological disability

- It aims to recruit 20,000 patients world-wide

- CRASH is an international multi-centre trial and has been funded by the UK Medical Research Council

- Like all such trials it depends on strong collaboration. It will require the collaboration of hundreds of doctors and nurses internationally in order to be a success