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Also,
while clearance is obviously slow for insoluble particles, at one point an equilibrium
will exist. For example, coal miners will have about 5 to 15 mg of coal dust/g of lung
despite chronic exposure. Note: Despite the
availability of computer models, clearance of insoluble particles in chronic exposures can
be dependent upon exposure concentration, particularly at high concentrations. See Morrow,
P. E., Haseman, J. K., Hobbs, C. H., Driscoll, K. E., Vu, V. and Oberdorster, G. The
maximum tolerated dose for inhalation bioassays: toxicity vs. overload. Fund. Appl.
Toxicol. 29, 155-167, 1996.
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INFLUENCING THE DOSE FOR GASES, VAPORS"
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