Note: Water/Gas and Blood/Gas S values are usually close. However sometimes (as below) the Blood/Gas S values can be much higher than Water/Gas. This will occur when protein(s) in blood has a high affinity for the substance. A good example is carbon disulfide for which hemoglobin has a very high affinity. The best examples are oxygen and carbon monoxide for which hemoglobin has a very high affinity. Thus one must be careful about S values for Water/Gas, however they are a good starting point if S value for Blood/Gas is not known. S values for Blood/Gas may also vary from species to species.

Two recent articles should be consulted on partition coefficients for nonreactive volatile organics: Poulin, P. and Krishnan, K. A tissue composition-based algorithm for predicting tissue: air partition coefficients of organic chemicals. Toxicol. Appl. Pharmacol. 136, 126-130, 1996. Poulin, P. and Krishnan, K. A mechanistic algorithm for predicting blood: air partition coefficients of organic chemicals with the consideration of reversible binding in hemoglobin. Toxicol. Appl. Pharmacol. 136, 131-137, 1996