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Fig.11. Neuroleptic drugs block at DA-ergic, 5-HT-ergic as well as at adrenergic, cholinergic and histamin-binding receptors.
So, antipsychotic action of antipsychotics also depend on a specific profile of action of the drugs on several neurotransmitter receptors, such as  5-HT,  α1-adrenoceptor, M-cholinoceptor, H1-receptor blocking action.
Antipsychotic drugs show varying patterns of selectivity in their receptor-blocking effects (tab.), some having affinity for 5-HT and/or D4 receptors.