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The ENO power plant, located in the center of the district of Prievidza, has been producing energy since 1953 by burning an arsenic-rich coal. The high content of arsenic in the coal (~ 520 µg/g) and in the fly ash (~860 µg/g) and the insufficient emission control measures resulted in the pollution of this Slovak region up to 1990

Keegan T, Hong B, Thornton I et al.

Assessment of environmental arsenic levels in Prievidza district.

J Expo Anal Environ Epidemiol 2002;12:179-85

The district of Prievidza ranks among the highly industrialized and most polluted areas in Central Slovakia. In the vicinity of the power plant, there is a large plant of the chlorine chemistry, also contributing to the environmental pollution of this area.

Discuss, if the potential effect of the spatially co-varying exposure by this chemical plant can be disentangled from the power plant effect on skin cancer risk respectively incidence?