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Anchor-based methods:

(McMaster Univ. group, Guyatt et al.; Osoba and colleagues)

Anchoring means matching or drawing a correspondence.

You can also anchor differences to clinical parameters at a single time point (I.e., baseline levels of disease symptoms or performance status)

Distribution-based methods:

SDs can be observed at a single time point or we can look at SDs of changes in HRQoL over time.

SEM: The margin of error that can be expected in an individualís score due to unreliability in the measurement. The amount of error that obscures the true score. 1 SEM has been recognized as providing a reasonable estimate of a CMC. Wyrwich et al.