prev next front |1 |2 |3 |4 |5 |6 |7 |8 |9 |10 |11 |12 |13 |14 |15 |16 |17 |18 |19 |20 |21 |22 |23 |24 |25 |26 |27 |28 |29 |30 |31 |32 |33 |review
Interleukin-6 (IL-6) is a pleiotropic cytokine that is produced by leukocytes, endothelial cells, and many other cell types. IL-6 is a secreted glycoprotein that binds to gp130 and gp80 (IL-6r) complex and is thought to regulate production of other acute phase reactants by the liver. IL-6 has also been noted to be induced by ischemia/reperfusion injury. Levels of IL-6 were associated with increased cardiovascular risk in the Women's Health Study. The levels of IL-6 were increased in women with cardiovascular events, and the odds ratio for women in the fourth quartile of IL-6 was 2.2 (confidence interval 1.14.3). Even women with median levels of total cholesterol appeared to have some increased risk if they had high levels of IL-6. However, IL-6 was not an independent predictor after adjustment for other cardiovascular risk factors in this study.

Ridker PM, Hennekens CH, Buring JE, Rifai N. C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women. N Engl J Med 2000;342:836-843.

Go to Part II of this lecture

Go to Comment Form