clinical consideration is the generalizability of these data, particularly to women. In
the Women's Health Study, a prospective cohort of some 38,000 middle-aged, predominantly
postmenopausal American women who were free of cardiovascular disease at study entry, the
relative risk of future vascular events increased as the level of C-reactive protein went
from low-normal to high-normal. This was true for all vascular events as well as for the
specific combined endpoint of MI or stroke.
Ridker PM, Buring JE, Shih J, Matias M, Hennekens CH. Prospective study of C-reactive
protein and the risk of future cardiovascular events among apparently healthy women.
WebsiteRidker PM et al. Circulation