intriguing observation concerning CRP and vascular risk is that the relative risk of a
future thromoembolic stroke also increases as the level of inflammation as measured by
hs-CRP goes from low-normal to high-normal. These data are of great interest because lipid
levels, in particular low-density lipoprotein (LDL) cholesterol, are very poor markers of
the risk of stroke, yet we know from the statin trials that lipid reduction reduces the
risk of stroke. Part of our group's interest in potential nonlipid mechanisms of statin
effects derive from this simple observation.
Ridker PM, Cushman M, Stampfer MJ, Tracy RP, Hennekens CH. Inflammation, aspirin, and the
risk of cardiovascular disease in apparently healthy men. N Engl J Med 1997;336:973-979.
Websiteidker PM et al. N Engl J Med