importance in coronary heart disease risk assessment is the issue of CRP screening. In
this prospective evaluation of middle-aged men in the Physicians' Health Study, the single
strongest predictor of risk was high-sensitivity CRP (hs-CRP) level, but the best marker
overall was the combination of hs-CRP and the total cholesterol:HDL-C ratio. These data
suggest consistency between large-scale studies, which is an important issue for clinical
Ridker PM. Evaluating novel cardiovascular risk factors: can we better predict heart
attacks? Ann Intern Med 1999;130:933-937.