C=coronary events defined as fatal/nonfatal myocardial infarction, sudden death, and unstable angina;

MI=fatal/nonfatal myocardial infarction; UA=unstable angina;

RV=revascularizations.

Downs JR et al. JAMA. 1998;279:1615-1622.

Subjects: 6,605; 85% men, 45-73 yr ; 15% women, 55-73 yr

Baseline lipids: TC: 221 mg/dL; LDL-C: 150 mg/dL ;

HDL-C: men, 36 mg/dL ; women, 40 mg/dLIntervention: Lovastatin 20-40 mg/day