hs-CRP and risk of future cardiovascular events in apparently healthy women

An important clinical consideration is the generalizability of these data, particularly to women.  In the Women's Health Study, a prospective cohort of some 38,000 middle-aged, predominantly postmenopausal American women who were free of cardiovascular disease at study entry, the relative risk of future vascular events increased as the level of C-reactive protein went from low-normal to high-normal.  This was true for all vascular events as well as for the specific combined endpoint of MI or stroke.

Reference:

Ridker PM, Buring JE, Shih J, Matias M, Hennekens CH. Prospective study of C-reactive protein and the risk of future cardiovascular events among apparently healthy women. Circulation 1998;98:731-733.

http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9727541&dopt=Abstract

Keywords:  C-reactive protein, Women's Health Study

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