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Rupture
of atherosclerotic plaque and subsequent thrombosis of the vessel is
responsible for the development of acute ischemic coronary syndromes. A
lipid-rich core (particularly in the shoulder regions of lesions), abundance
of inflammatory cells, a thin fibrous cap and dysfunctional overlying
endothelium characterize plaques that are prone to rupture.
Reference Weissberg PL. Eur Heart J Supplements 1999:1:T13 –18.
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