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C. Thomas Caskey, Annu. Rev. Med. 2007. 58:1–16

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Table 1, Numbers of New Small Molecule Drug Approvals per Year (NMEs) Compared to New Biologic Drug Approvals (new BLAs) 1988-2008. (Ref. 3)  Biologics here are not restricted to monoclonal antibodies, cytokines, tissue growth factors and therapeutic proteins.  Last line* shows therapeutic proteins and Mabs from Ref 4, 5.