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Rosenbaum and Witman, Nature Reviews Mol Cell Biol (2002)
Introduce the structure: Solitary projection; basal body; size Why the recent interest-- Polycystic Kidney Disease; Bardet Biedl Syndrome --General Components of Signaling.
Kathryn Anderson: Mutants in IFT; Kinesin; Dyenin all have Hh phenotypes
Studying signaling in this structure is a technical challenge. It has required the development of new way to study signaling using high resolution microscopy and new optical probes to follow protains, We have started to unravel the cell biology of how Hh signaling depends on primary cilia. |