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Increased eosinophils in asthmatics also contribute to airway remodeling. These slides are again from the Barbato and colleagues study of school aged children with asthma. *Remember from our notes that eosinophils have an affinity for red dye. Slide A represents a bronchial biopsy from an asthmatic child and the red areas are indicative of increased numbers of eosinophils infiltrating the subepithelium. Slide B is a control child without asthma.

*Just to summarize thus far, we have covered that asthma is characterized by an inflammatory response initiating a cascade of cellular events and these events lead to or occur simultaneously with airway remodeling.